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Crystal Structure of the Eosinophil Major Basic Protein at 1.8A: An Atypical Lectin with a Paradigm Shift in Specificity

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: immune response
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00059
Domain description: Lectin C-type domain
Occurring in:
  1. Eosinophil granule major basic protein
The deposited structure of PDB entry 1h8u contains 2 copies of Pfam domain PF00059 (Lectin C-type domain) in Eosinophil granule major basic protein. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002352
Domain description: Eosinophil major basic protein
Occurring in:
  1. Eosinophil granule major basic protein
IPR001304
Domain description: C-type lectin-like
Occurring in:
  1. Eosinophil granule major basic protein
IPR018378
Domain description: C-type lectin, conserved site
Occurring in:
  1. Eosinophil granule major basic protein
IPR016187
Domain description: C-type lectin fold
Occurring in:
  1. Eosinophil granule major basic protein
IPR033816
Domain description: Eosinophil major basic protein, C-type lectin-like domain
Occurring in:
  1. Eosinophil granule major basic protein
IPR016186
Domain description: C-type lectin-like/link domain superfamily
Occurring in:
  1. Eosinophil granule major basic protein

Structure domain

CATH CATH domain
3.10.100.10
Class: Alpha Beta
Architecture: Roll
Topology: Mannose-Binding Protein A; Chain A
Homology: Mannose-Binding Protein A, subunit A
Occurring in:
  1. Eosinophil granule major basic protein
The deposited structure of PDB entry 1h8u contains 2 copies of CATH domain 3.10.100.10 (Mannose-Binding Protein A; Chain A) in Eosinophil granule major basic protein. Showing 1 copy in chain B.
SCOP SCOP annotation
56437
Class: Alpha and beta proteins (a+b)
Fold: C-type lectin-like
Superfamily: C-type lectin-like
Occurring in:
  1. Eosinophil granule major basic protein
The deposited structure of PDB entry 1h8u contains 2 copies of SCOP domain 56437 (C-type lectin domain) in Eosinophil granule major basic protein. Showing 1 copy in chain B.

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