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N-ACETYLNEURAMINATE LYASE IN COMPLEX WITH PYRUVATE VIA BOROHYDRIDE REDUCTION

X-ray diffraction
2.6Å resolution
PDB entry 1fdz coloured by chain, front view.
PDB entry 1fdz coloured by chain, side view.
PDB entry 1fdz coloured by chain, top view.
Source organism: Escherichia coli
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: N-acetylneuraminate lyase
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Multimeric state: homo tetramer
Accessible surface area: 39644.78 Å2
Buried surface area: 9534.32 Å2
Dissociation area: 1,994.1 Å2
Dissociation energy (ΔGdiss): 16.53 kcal/mol
Dissociation entropy (TΔSdiss): 14.9 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-141379

Macromolecules

N-acetylneuraminate lyase
Chains: A, B, C, D
Length: 297 amino acids
Theoretical weight: 32.63 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A6L4 (Residues: 1-297; Coverage: 100%)
Gene names: JW3194, b3225, nanA, npl
Pfam: Dihydrodipicolinate synthetase family
InterPro:
CATH: Aldolase class I
SCOP: Class I aldolase
N-acetylneuraminate lyase in PDB entry 1fdz, assembly 1, front view.
N-acetylneuraminate lyase in PDB entry 1fdz, assembly 1, side view.
N-acetylneuraminate lyase in PDB entry 1fdz, assembly 1, top view.
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