N-acetylneuraminate lyase (IPR005264)

Short name: NanA

Overlapping homologous superfamilies

Family relationships

  • DapA-like (IPR002220)
    • N-acetylneuraminate lyase (IPR005264)


N-acetylneuraminate lyase (or N-Acetylneuraminic acid aldolase, NAL) catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetyl-D-mannosamine. The enzyme plays an important role in the regulation of sialic acid metabolism in bacteria. It has a widespread application as biocatalyst for the synthesis of sialic acid and its derivatives [PMID: 11432751]. This enzyme has been shown to be quite specific for pyruvate as the donor, but flexible to a variety of D- and, to some extent, L-hexoses and pentoses as acceptor substrates. NAL is member of dihydrodipicolinate synthase family that comprises several pyruvate-dependent class I aldolases [PMID: 12711733].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0008747 N-acetylneuraminate lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.