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CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION

X-ray diffraction
2.6Å resolution
PDB entry 1cqp coloured by chain, front view.
PDB entry 1cqp coloured by chain, side view.
PDB entry 1cqp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Integrin alpha-L
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Multimeric state: monomeric
Accessible surface area: 9351.73 Å2
Buried surface area: 843.48 Å2
Dissociation area: 369.36 Å2
Dissociation energy (ΔGdiss): -6.95 kcal/mol
Dissociation entropy (TΔSdiss): 4.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149031
Assembly 2
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Assembly Name: Integrin alpha-L
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Multimeric state: monomeric
Accessible surface area: 9157.44 Å2
Buried surface area: 808.01 Å2
Dissociation area: 351.15 Å2
Dissociation energy (ΔGdiss): -7.1 kcal/mol
Dissociation entropy (TΔSdiss): 4.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149031

Macromolecules

Integrin alpha-L
Chains: A, B
Length: 182 amino acids
Theoretical weight: 20.82 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20701 (Residues: 153-334; Coverage: 16%)
Gene names: CD11A, ITGAL
Pfam: von Willebrand factor type A domain
InterPro:
CATH: von Willebrand factor, type A domain
SCOP: Integrin A (or I) domain
Integrin alpha-L in PDB entry 1cqp, assembly 1, front view.
Integrin alpha-L in PDB entry 1cqp, assembly 1, side view.
Integrin alpha-L in PDB entry 1cqp, assembly 1, top view.
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