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STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE

Source organism: Escherichia coli K-12
Biochemical function: pentosyltransferase activity
Biological process: thymidine metabolic process
Cellular component: membrane

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EC 2.4.2.4: Thymidine phosphorylase

Reaction catalysed:
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Systematic name:
Thymidine:phosphate deoxy-alpha-D-ribosyltransferase
Alternative Name(s):
  • Animal growth regulators, blood platelet-derived endothelial cell growth factors
  • Blood platelet-derived endothelial cell growth factor
  • Deoxythymidine phosphorylase
  • Gliostatins
  • Pyrimidine deoxynucleoside phosphorylase
  • Pyrimidine phosphorylase
  • Thymidine-orthophosphate deoxyribosyltransferase
  • Thymidine:phosphate deoxy-D-ribosyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF07831
Domain description: Pyrimidine nucleoside phosphorylase C-terminal domain
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of Pfam domain PF07831 (Pyrimidine nucleoside phosphorylase C-terminal domain) in Thymidine phosphorylase. Showing 1 copy in chain A.

PF00591
Domain description: Glycosyl transferase family, a/b domain
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of Pfam domain PF00591 (Glycosyl transferase family, a/b domain) in Thymidine phosphorylase. Showing 1 copy in chain A.

PF02885
Domain description: Glycosyl transferase family, helical bundle domain
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of Pfam domain PF02885 (Glycosyl transferase family, helical bundle domain) in Thymidine phosphorylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013102
Domain description: Pyrimidine nucleoside phosphorylase, C-terminal
Occurring in:
  1. Thymidine phosphorylase
IPR036566
Domain description: Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily
Occurring in:
  1. Thymidine phosphorylase
IPR035902
Domain description: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
Occurring in:
  1. Thymidine phosphorylase
IPR000053
Domain description: Thymidine/pyrimidine-nucleoside phosphorylase
Occurring in:
  1. Thymidine phosphorylase
IPR017872
Domain description: Pyrimidine-nucleoside phosphorylase, conserved site
Occurring in:
  1. Thymidine phosphorylase
IPR000312
Domain description: Glycosyl transferase, family 3
Occurring in:
  1. Thymidine phosphorylase
IPR017459
Domain description: Glycosyl transferase family 3, N-terminal domain
Occurring in:
  1. Thymidine phosphorylase
IPR018090
Domain description: Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic
Occurring in:
  1. Thymidine phosphorylase
IPR036320
Domain description: Glycosyl transferase family 3, N-terminal domain superfamily
Occurring in:
  1. Thymidine phosphorylase
IPR013465
Domain description: Thymidine phosphorylase
Occurring in:
  1. Thymidine phosphorylase

Structure domains

CATH CATH domains
3.40.1030.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
Homology: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of CATH domain 3.40.1030.10 (Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2) in Thymidine phosphorylase. Showing 1 copy in chain A.
1.20.970.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homology: Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of CATH domain 1.20.970.10 (Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3) in Thymidine phosphorylase. Showing 1 copy in chain A.
3.90.1170.30
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aldehyde Oxidoreductase; domain 3
Homology: Pyrimidine nucleoside phosphorylase-like, C-terminal domain
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of CATH domain 3.90.1170.30 (Aldehyde Oxidoreductase; domain 3) in Thymidine phosphorylase. Showing 1 copy in chain A.
SCOP SCOP annotations
54681
Class: Alpha and beta proteins (a+b)
Fold: alpha/beta-Hammerhead
Superfamily: Pyrimidine nucleoside phosphorylase C-terminal domain
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of SCOP domain 54681 (Pyrimidine nucleoside phosphorylase C-terminal domain) in Thymidine phosphorylase. Showing 1 copy in chain A.
52419
Class: Alpha and beta proteins (a/b)
Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of SCOP domain 52419 (Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain) in Thymidine phosphorylase. Showing 1 copy in chain A.
47649
Class: All alpha proteins
Fold: Methionine synthase domain-like
Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
Occurring in:
  1. Thymidine phosphorylase
The deposited structure of PDB entry 1azy contains 2 copies of SCOP domain 47649 (Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain) in Thymidine phosphorylase. Showing 1 copy in chain A.

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