Homologous Superfamily

Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily (IPR035902)

Short name: Nuc_phospho_transferase

Overlapping entries

Description

The nucleoside phosphorylase and the phosphoribosyltransferase catalytic domain belongs to the glycosyl transferase family. The glycosyl transferase family includes anthranilate phosphoribosyltransferase (TrpD, EC:2.4.2.18) and thymidine phosphorylase (EC:2.4.2.2). All these proteins can transfer a phosphorylated ribose substrate. Thymidine phosphorylase (EC:2.4.2.2) catalyses the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate. This enzyme regulates the availability of thymidine and is therefore essential to nucleic acid metabolism.

The structure is composed of three layers (alpha/beta/alpha) arranged in parallel beta-sheets of five strands.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D