Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily (IPR035902)
Short name: Nuc_phospho_transferase
- Thymidine/pyrimidine-nucleoside phosphorylase (IPR000053)
- Glycosyl transferase, family 3 (IPR000312)
- Anthranilate phosphoribosyl transferase (IPR005940)
- Thymidine phosphorylase (IPR013465)
- Thymidine phosphorylase/AMP phosphorylase (IPR013466)
- AMP phosphorylase (IPR017713)
- Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic (IPR018090)
- Putative thymidine phosphorylase (IPR028579)
The nucleoside phosphorylase and the phosphoribosyltransferase catalytic domain belongs to the glycosyl transferase family. The glycosyl transferase family includes anthranilate phosphoribosyltransferase (TrpD, EC:188.8.131.52) and thymidine phosphorylase (EC:184.108.40.206). All these proteins can transfer a phosphorylated ribose substrate. Thymidine phosphorylase (EC:220.127.116.11) catalyses the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate. This enzyme regulates the availability of thymidine and is therefore essential to nucleic acid metabolism.
The structure is composed of three layers (alpha/beta/alpha) arranged in parallel beta-sheets of five strands.