7nxd

Electron Microscopy
4.6Å resolution

Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-138710 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Integrin alpha-5 Chain: A
Molecule details ›
Chain: A
Length: 1008 amino acids
Theoretical weight: 110.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08648 (Residues: 42-1049; Coverage: 100%)
Gene names: FNRA, ITGA5
Sequence domains:
Integrin beta-1 Chain: B
Molecule details ›
Chain: B
Length: 778 amino acids
Theoretical weight: 86.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05556 (Residues: 21-798; Coverage: 100%)
Gene names: FNRB, ITGB1, MDF2, MSK12
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.6Å
Relevant EMDB volumes: EMD-12637