› 5ymr

X-ray diffraction
2.4Å resolution

Function and Biology Details

Reaction catalysed: 
Isethionate = acetaldehyde + sulfite
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180782 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isethionate sulfite-lyase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 808 amino acids
Theoretical weight: 91.46 KDa
Source organism: Desulfovibrio vulgaris str. Hildenborough
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q727N1 (Residues: 24-828; Coverage: 97%)
Gene names: DVU_2824, iseG
Sequence domains:
Structure domains: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain

Ligands and Environments

2 bound ligands:
Ligand 8X3 4 x 8X3
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 110.111Å b: 159.444Å c: 115.378Å
α: 90° β: 91.66° γ: 90°
R-values:
R R work R free
0.217 0.212 0.262
Expression system: Escherichia coli K-12

Quick links

Citations

6 review citations

The metabolic nature of inflammatory bowel diseases.
Adolph et al. (2022)
5 more

4 mentions without citation

Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate.
Liu et al. (2020)
3 more