Pyruvate formate lyase domain (IPR004184)

Short name: PFL_dom

Overlapping homologous superfamilies


Domain relationships



Pyruvate formate lyase (PFL) catalyzes the non-oxidative conversion of pyruvate and CoA to formate and acetyl-CoA. Several other enzymes have been identified in the pyruvate formate lyase family: ketoacid formate lyase, glycerol dehydratase (GD), benzyl succinate synthetase and p-hydroxyphenylacetate decarboxylase [PMID: 10425676, PMID: 16414072].

The PFL domain has a unique alpha/beta barrel arrangement, with five 'up' strands and three 'down' strands; the up and down strands are linked by a unique beta finger that carries a key thiyl radical [PMID: 10425676, PMID: 16414072].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles