Glycine radical domain (IPR001150)

Short name: Gly_radical

Overlapping homologous superfamilies


Domain relationships



Glycyl radical enzymes are involved in a great variety of functions, including nucleotide, pyruvate and toluene metabolism [PMID: 10574800]. A glycyl radical is formed by the removal of a hydrogen from a glycine and the resulting radical is located on the protein main chain.

Escherichia coli formate C-acetyltransferase (EC: is a key enzyme of anaerobic glucose metabolism; it converts pyruvate and CoA into acetyl-CoA and pyruvate. It is posttranslationally interconverted, under anaerobic conditions, from an inactive to an active form that carries a stable radical localized to a specific glycine at the C terminus [PMID: 1310545]. Such a glycine radical is also be present in E. coli (gene nrdD) [PMID: 8421692] and Bacteriophage T4 (gene nrdD or sunY) anaerobic ribonucleoside-triphosphate reductases (EC: In these enzymes the glycyl radical is located at the C-terminal part of the enzyme [PMID: 8702830]. An autonomous glycyl radical cofactor also exists in Escherichia coli and bacteriophage T4 (gene grcA) [PMID: 11444864].

This entry represents a domain covering the conserved region around the glycine radical.

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles