› 3tsd

X-ray diffraction
2.65Å resolution

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 511 amino acids
Theoretical weight: 55.18 KDa
Source organism: Bacillus anthracis str. Ames
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A6L8P2U9 (Residues: 1-487; Coverage: 100%)
Gene names: GBAA_0008, guaB
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:
Ligand XMP 2 x XMP
Ligand TAR 1 x TAR
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I4
Unit cell:
a: 123.25Å b: 123.25Å c: 141.636Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.245
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

CBS domains: Ligand binding sites and conformational variability.
Ereño-Orbea et al. (2013)
3 more

6 mentions without citation

Redox regulation by reversible protein S-thiolation in Gram-positive bacteria.
Imber et al. (2019)
5 more