Inosine-5'-monophosphate dehydrogenase (IPR005990)

Short name: IMP_DH

Overlapping homologous superfamilies

Family relationships


This entry includes inosine-5'-monophosphate dehydrogenases and guanosine 5'-monophosphate (GMP) reductase. Inosine-5'-monophosphate dehydrogenase catalyses the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth [PMID: 8980752, PMID: 11223253]. GMP catalyses the irreversible NADPH-dependent deamination of GMP to IMP [PMID: 7159467].

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0003938 IMP dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.