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{
"metadata": {
"accession": "PF21126",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR048611",
"hierarchy": null,
"name": {
"name": "Katanin p60 subunit A1, MIT domain",
"short": "KATNA1_MIT"
},
"description": [
{
"text": "<p>Katanin is an ATP-dependent microtubule severing protein composed of 60kDa (katanin-p60) and 80kDa (katanin-p80) subunits (KATNA1 and KATNB1, respectively) [[cite:PUB00069769],[cite:PUB00145862],[cite:PUB00068822],[cite:PUB00092939]]. In mammals, there are two additional A-like subunits (KATNAL1 and KATNAL2) and one additional B-like subunit (KATNBL1) [[cite:PUB00092939]]. KATNA1 has the enzymatic activity for microtubule severing and plays a key role in cytoskeletal reorganisation, while KATNB is the regulatory subunit. Formation of the katanin A/B heterodimer is mediated by the N-terminal Microtubule Interacting and Trafficking domain (MIT, represented in this entry) of KATNA1/KATNAL1) and a conserved C-terminal domain of KATNB [[cite:PUB00145862]]. This domain is organised in an antiparallel three-helix bundle [[cite:PUB00069769]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00145862": {
"PMID": 28436967,
"ISBN": null,
"volume": "19",
"issue": "5",
"year": 2017,
"title": "Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.",
"URL": null,
"raw_pages": "480-492",
"medline_journal": "Nat Cell Biol",
"ISO_journal": "Nat Cell Biol",
"authors": [
"Jiang K",
"Rezabkova L",
"Hua S",
"Liu Q",
"Capitani G",
"Altelaar AFM",
"Heck AJR",
"Kammerer RA",
"Steinmetz MO",
"Akhmanova A."
],
"DOI_URL": null
},
"PUB00092939": {
"PMID": 26929214,
"ISBN": null,
"volume": "15",
"issue": "5",
"year": 2016,
"title": "Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.",
"URL": null,
"raw_pages": "1658-69",
"medline_journal": "Mol Cell Proteomics",
"ISO_journal": "Mol. Cell Proteomics",
"authors": [
"Cheung K",
"Senese S",
"Kuang J",
"Bui N",
"Ongpipattanakul C",
"Gholkar A",
"Cohn W",
"Capri J",
"Whitelegge JP",
"Torres JZ."
],
"DOI_URL": null
},
"PUB00068822": {
"PMID": 23894477,
"ISBN": null,
"volume": "8",
"issue": "7",
"year": 2013,
"title": "Katanin-p80 gene promoter characterization and regulation via Elk1.",
"URL": null,
"raw_pages": "e69423",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS ONE",
"authors": [
"Selcuk E",
"Kırımtay K",
"Canbaz D",
"Cesur GI",
"Korulu S",
"Karabay A."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.pone.0069423"
},
"PUB00069769": {
"PMID": 20339000,
"ISBN": null,
"volume": "285",
"issue": "22",
"year": 2010,
"title": "A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.",
"URL": null,
"raw_pages": "16822-9",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Iwaya N",
"Kuwahara Y",
"Fujiwara Y",
"Goda N",
"Tenno T",
"Akiyama K",
"Mase S",
"Tochio H",
"Ikegami T",
"Shirakawa M",
"Hiroaki H."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M110.108365"
}
},
"set_info": {
"accession": "CL0745",
"name": "MIT"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 48,
"interactions": 0,
"matches": 3422,
"pathways": 0,
"proteins": 3420,
"proteomes": 1579,
"sets": 1,
"structural_models": {
"alphafold": 3128,
"bfvd": 0
},
"structures": 5,
"taxa": 5344
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 21,
"alignment:full": 2387
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "5lb7",
"name": "Complex structure between p60N/p80C katanin and a peptide derived from ASPM"
}
}
}
