{"metadata":{"accession":"PF21126","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048611","hierarchy":null,"name":{"name":"Katanin p60 subunit A1, MIT domain","short":"KATNA1_MIT"},"description":[{"text":"<p>Katanin is an ATP-dependent microtubule severing protein composed of 60kDa (katanin-p60) and 80kDa (katanin-p80) subunits (KATNA1 and KATNB1, respectively) [[cite:PUB00069769],[cite:PUB00145862],[cite:PUB00068822],[cite:PUB00092939]]. In mammals, there are two additional A-like subunits (KATNAL1 and KATNAL2) and one additional B-like subunit (KATNBL1) [[cite:PUB00092939]]. KATNA1 has the enzymatic activity for microtubule severing and plays a key role in cytoskeletal reorganisation, while KATNB is the regulatory subunit. Formation of the katanin A/B heterodimer is mediated by the N-terminal Microtubule Interacting and Trafficking domain (MIT, represented in this entry) of KATNA1/KATNAL1) and a conserved C-terminal domain of KATNB [[cite:PUB00145862]]. This domain is organised in an antiparallel three-helix bundle [[cite:PUB00069769]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00145862":{"PMID":28436967,"ISBN":null,"volume":"19","issue":"5","year":2017,"title":"Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.","URL":null,"raw_pages":"480-492","medline_journal":"Nat Cell Biol","ISO_journal":"Nat Cell Biol","authors":["Jiang K","Rezabkova L","Hua S","Liu Q","Capitani G","Altelaar AFM","Heck AJR","Kammerer RA","Steinmetz MO","Akhmanova A."],"DOI_URL":null},"PUB00092939":{"PMID":26929214,"ISBN":null,"volume":"15","issue":"5","year":2016,"title":"Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.","URL":null,"raw_pages":"1658-69","medline_journal":"Mol Cell Proteomics","ISO_journal":"Mol. Cell Proteomics","authors":["Cheung K","Senese S","Kuang J","Bui N","Ongpipattanakul C","Gholkar A","Cohn W","Capri J","Whitelegge JP","Torres JZ."],"DOI_URL":null},"PUB00068822":{"PMID":23894477,"ISBN":null,"volume":"8","issue":"7","year":2013,"title":"Katanin-p80 gene promoter characterization and regulation via Elk1.","URL":null,"raw_pages":"e69423","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Selcuk E","Kırımtay K","Canbaz D","Cesur GI","Korulu S","Karabay A."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pone.0069423"},"PUB00069769":{"PMID":20339000,"ISBN":null,"volume":"285","issue":"22","year":2010,"title":"A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.","URL":null,"raw_pages":"16822-9","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Iwaya N","Kuwahara Y","Fujiwara Y","Goda N","Tenno T","Akiyama K","Mase S","Tochio H","Ikegami T","Shirakawa M","Hiroaki H."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M110.108365"}},"set_info":{"accession":"CL0745","name":"MIT"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":48,"interactions":0,"matches":3422,"pathways":0,"proteins":3420,"proteomes":1579,"sets":1,"structural_models":{"alphafold":3128,"bfvd":0},"structures":5,"taxa":5344},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":21,"alignment:full":2387},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5lb7","name":"Complex structure between p60N/p80C katanin and a peptide derived from ASPM"}}}