"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"PF21126"	"{'subfamilies': 0, 'domain_architectures': 43, 'interactions': 0, 'matches': 3110, 'pathways': 0, 'proteins': 3110, 'proteomes': 1621, 'sets': 1, 'structural_models': {'alphafold': 2745}, 'structures': 5, 'taxa': 5214}"	"{}"	"[{'text': '<p>Katanin is an ATP-dependent microtubule severing protein composed of 60kDa (katanin-p60) and 80kDa (katanin-p80) subunits (KATNA1 and KATNB1, respectively) [[cite:PUB00069769],[cite:PUB00145862],[cite:PUB00068822],[cite:PUB00092939]]. In mammals, there are two additional A-like subunits (KATNAL1 and KATNAL2) and one additional B-like subunit (KATNBL1) [[cite:PUB00092939]]. KATNA1 has the enzymatic activity for microtubule severing and plays a key role in cytoskeletal reorganisation, while KATNB is the regulatory subunit. Formation of the katanin A/B heterodimer is mediated by the N-terminal Microtubule Interacting and Trafficking domain (MIT, represented in this entry) of KATNA1/KATNAL1) and a conserved C-terminal domain of KATNB [[cite:PUB00145862]]. This domain is organised in an antiparallel three-helix bundle [[cite:PUB00069769]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR048611"	False	False	False	"{'PUB00092939': {'PMID': 26929214, 'ISBN': None, 'volume': '15', 'issue': '5', 'year': 2016, 'title': 'Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.', 'URL': None, 'raw_pages': '1658-69', 'medline_journal': 'Mol Cell Proteomics', 'ISO_journal': 'Mol. Cell Proteomics', 'authors': ['Cheung K', 'Senese S', 'Kuang J', 'Bui N', 'Ongpipattanakul C', 'Gholkar A', 'Cohn W', 'Capri J', 'Whitelegge JP', 'Torres JZ.'], 'DOI_URL': None}, 'PUB00068822': {'PMID': 23894477, 'ISBN': None, 'volume': '8', 'issue': '7', 'year': 2013, 'title': 'Katanin-p80 gene promoter characterization and regulation via Elk1.', 'URL': None, 'raw_pages': 'e69423', 'medline_journal': 'PLoS One', 'ISO_journal': 'PLoS ONE', 'authors': ['Selcuk E', 'Kırımtay K', 'Canbaz D', 'Cesur GI', 'Korulu S', 'Karabay A.'], 'DOI_URL': 'http://dx.doi.org/10.1371/journal.pone.0069423'}, 'PUB00145862': {'PMID': 28436967, 'ISBN': None, 'volume': '19', 'issue': '5', 'year': 2017, 'title': 'Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.', 'URL': None, 'raw_pages': '480-492', 'medline_journal': 'Nat Cell Biol', 'ISO_journal': 'Nat Cell Biol', 'authors': ['Jiang K', 'Rezabkova L', 'Hua S', 'Liu Q', 'Capitani G', 'Altelaar AFM', 'Heck AJR', 'Kammerer RA', 'Steinmetz MO', 'Akhmanova A.'], 'DOI_URL': None}, 'PUB00069769': {'PMID': 20339000, 'ISBN': None, 'volume': '285', 'issue': '22', 'year': 2010, 'title': 'A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.', 'URL': None, 'raw_pages': '16822-9', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J. Biol. Chem.', 'authors': ['Iwaya N', 'Kuwahara Y', 'Fujiwara Y', 'Goda N', 'Tenno T', 'Akiyama K', 'Mase S', 'Tochio H', 'Ikegami T', 'Shirakawa M', 'Hiroaki H.'], 'DOI_URL': 'http://dx.doi.org/10.1074/jbc.M110.108365'}}"	""	"{'name': 'Katanin p60 subunit A1, MIT domain', 'short': 'KATNA1_MIT'}"	""	"{'accession': '5lb7', 'name': 'Complex structure between p60N/p80C katanin and a peptide derived from ASPM'}"	"{'accession': 'CL0745', 'name': 'MIT'}"	"pfam"	"domain"	""