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{
"metadata": {
"accession": "PF11719",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR021110",
"hierarchy": null,
"name": {
"name": "DNA replication and checkpoint protein",
"short": "Drc1-Sld2"
},
"description": [
{
"text": "<p>Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent re-licensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5 [[cite:PUB00053358]]. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication [[cite:PUB00053359]].</p>",
"llm": false,
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}
],
"wikipedia": null,
"literature": {
"PUB00053359": {
"PMID": 17167415,
"ISBN": null,
"volume": "445",
"issue": "7125",
"year": 2007,
"title": "CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast.",
"URL": null,
"raw_pages": "328-32",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Tanaka S",
"Umemori T",
"Hirai K",
"Muramatsu S",
"Kamimura Y",
"Araki H."
],
"DOI_URL": "http://dx.doi.org/10.1038/nature05465"
},
"PUB00053358": {
"PMID": 11937031,
"ISBN": null,
"volume": "12",
"issue": "7",
"year": 2002,
"title": "CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.",
"URL": null,
"raw_pages": "599-605",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
"authors": [
"Noguchi E",
"Shanahan P",
"Noguchi C",
"Russell P."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0960-9822(02)00739-X"
}
},
"set_info": null,
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"counters": {
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"domain_architectures": 48,
"interactions": 0,
"matches": 2178,
"pathways": 0,
"proteins": 2145,
"proteomes": 1685,
"sets": 0,
"structural_models": {
"alphafold": 1599,
"bfvd": 0
},
"structures": 1,
"taxa": 4680
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 18,
"alignment:full": 1455
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
