{"metadata":{"accession":"PF11719","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021110","hierarchy":null,"name":{"name":"DNA replication and checkpoint protein","short":"Drc1-Sld2"},"description":[{"text":"<p>Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent re-licensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5 [[cite:PUB00053358]]. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication [[cite:PUB00053359]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00053359":{"PMID":17167415,"ISBN":null,"volume":"445","issue":"7125","year":2007,"title":"CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast.","URL":null,"raw_pages":"328-32","medline_journal":"Nature","ISO_journal":"Nature","authors":["Tanaka S","Umemori T","Hirai K","Muramatsu S","Kamimura Y","Araki H."],"DOI_URL":"http://dx.doi.org/10.1038/nature05465"},"PUB00053358":{"PMID":11937031,"ISBN":null,"volume":"12","issue":"7","year":2002,"title":"CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.","URL":null,"raw_pages":"599-605","medline_journal":"Curr Biol","ISO_journal":"Curr. Biol.","authors":["Noguchi E","Shanahan P","Noguchi C","Russell P."],"DOI_URL":"http://dx.doi.org/10.1016/S0960-9822(02)00739-X"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":48,"interactions":0,"matches":2178,"pathways":0,"proteins":2145,"proteomes":1685,"sets":0,"structural_models":{"alphafold":1599,"bfvd":0},"structures":1,"taxa":4680},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":1455},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}