"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"PF11719"	"{'subfamilies': 0, 'domain_architectures': 47, 'interactions': 0, 'matches': 1904, 'pathways': 0, 'proteins': 1880, 'proteomes': 1736, 'sets': 0, 'structural_models': {'alphafold': 1306}, 'structures': 1, 'taxa': 4567}"	"{}"	"[{'text': '<p>Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent re-licensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5 [[cite:PUB00053358]]. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication [[cite:PUB00053359]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR021110"	False	False	False	"{'PUB00053358': {'PMID': 11937031, 'ISBN': None, 'volume': '12', 'issue': '7', 'year': 2002, 'title': 'CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.', 'URL': None, 'raw_pages': '599-605', 'medline_journal': 'Curr Biol', 'ISO_journal': 'Curr. Biol.', 'authors': ['Noguchi E', 'Shanahan P', 'Noguchi C', 'Russell P.'], 'DOI_URL': 'http://dx.doi.org/10.1016/S0960-9822(02)00739-X'}, 'PUB00053359': {'PMID': 17167415, 'ISBN': None, 'volume': '445', 'issue': '7125', 'year': 2007, 'title': 'CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast.', 'URL': None, 'raw_pages': '328-32', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Tanaka S', 'Umemori T', 'Hirai K', 'Muramatsu S', 'Kamimura Y', 'Araki H.'], 'DOI_URL': 'http://dx.doi.org/10.1038/nature05465'}}"	""	"{'name': 'DNA replication and checkpoint protein', 'short': 'Drc1-Sld2'}"	""	""	""	"pfam"	"family"	""