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{
"metadata": {
"accession": "cd17126",
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"type": "domain",
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"source_database": "cdd",
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"name": {
"name": "ubiquitin-like (Ubl) domain found in UV excision repair protein RAD23 homolog A (HR23A)",
"short": "Ubl_HR23A"
},
"description": [
{
"text": "<p>HR23A, also termed RAD23A, is a DNA repair protein that binds to 19S subunit of the 26S proteasome and shuttles ubiquitinated proteins to the proteasome for degradation, which is required for efficient nucleotide excision repair (NER), a primary mechanism for removing UV-induced DNA lesions. HR23A also plays a critical role in the interaction of HIV-1 viral protein R (Vpr) with the proteasome, especially facilitating Vpr to promote protein poly-ubiquitination. HR23A contains an N-terminal ubiquitin-like (Ubl) domain that binds proteasomes and two C-terminal ubiquitin-associated (UBA) domains that bind ubiquitin or multi-ubiquitinated substrates. In addition, it has a XPC protein-binding domain that might be necessary for its efficient NER function. [[cite:PUB00108617], [cite:PUB00007089], [cite:PUB00108652], [cite:PUB00108621], [cite:PUB00108622], [cite:PUB00031529], [cite:PUB00029556], [cite:PUB00029780], [cite:PUB00003958], [cite:PUB00108623], [cite:PUB00108624], [cite:PUB00056581], [cite:PUB00108625], [cite:PUB00091873], [cite:PUB00019036], [cite:PUB00108626], [cite:PUB00108627], [cite:PUB00020522], [cite:PUB00108628], [cite:PUB00108629], [cite:PUB00108630], [cite:PUB00024785], [cite:PUB00108618], [cite:PUB00108651]]</p>",
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"issue": "11",
"year": 2003,
"title": "Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains.",
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"raw_pages": "8951-9",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Raasi S",
"Pickart CM."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M212841200"
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"volume": "65",
"issue": "Pt 9",
"year": 2009,
"title": "Crystallization and preliminary X-ray diffraction studies of the ubiquitin-like (UbL) domain of the human homologue A of Rad23 (hHR23A) protein.",
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"raw_pages": "930-2",
"medline_journal": "Acta Crystallogr Sect F Struct Biol Cryst Commun",
"ISO_journal": "Acta Crystallogr Sect F Struct Biol Cryst Commun",
"authors": [
"Chen YW",
"Tajima T",
"Rees M",
"Garcia-Maya M."
],
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},
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"volume": "341",
"issue": "5",
"year": 2004,
"title": "Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A.",
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"raw_pages": "1367-79",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Raasi S",
"Orlov I",
"Fleming KG",
"Pickart CM."
],
"DOI_URL": "https://doi.org/10.1016/j.jmb.2004.06.057"
},
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"title": "Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions.",
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"raw_pages": "1243-55",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Mueller TD",
"Feigon J."
],
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"title": "Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.",
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"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett",
"authors": [
"Chen L",
"Madura K."
],
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},
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"issue": "12",
"year": 1998,
"title": "Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr.",
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"raw_pages": "1042-7",
"medline_journal": "Nat Struct Biol",
"ISO_journal": "Nat. Struct. Biol.",
"authors": [
"Dieckmann T",
"Withers-Ward ES",
"Jarosinski MA",
"Liu CF",
"Chen IS",
"Feigon J."
],
"DOI_URL": "http://dx.doi.org/10.1038/4220"
},
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"volume": "17",
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"year": 1997,
"title": "Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.",
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"raw_pages": "6924-31",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Sugasawa K",
"Ng JM",
"Masutani C",
"Maekawa T",
"Uchida A",
"van der Spek PJ",
"Eker AP",
"Rademakers S",
"Visser C",
"Aboussekhra A",
"Wood RD",
"Hanaoka F",
"Bootsma D",
"Hoeijmakers JH."
],
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},
"PUB00108617": {
"PMID": 25311859,
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"volume": "426",
"issue": "24",
"year": 2014,
"title": "Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.",
"URL": null,
"raw_pages": "4049-4060",
"medline_journal": "J Mol Biol",
"ISO_journal": "J Mol Biol",
"authors": [
"Liang RY",
"Chen L",
"Ko BT",
"Shen YH",
"Li YT",
"Chen BR",
"Lin KT",
"Madura K",
"Chuang SM."
],
"DOI_URL": null
},
"PUB00029780": {
"PMID": 12970176,
"ISBN": null,
"volume": "22",
"issue": "18",
"year": 2003,
"title": "Structural determinants for the binding of ubiquitin-like domains to the proteasome.",
"URL": null,
"raw_pages": "4634-45",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Mueller TD",
"Feigon J."
],
"DOI_URL": "http://dx.doi.org/10.1093/emboj/cdg467"
},
"PUB00024785": {
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"ISBN": null,
"volume": "39",
"issue": "46",
"year": 2000,
"title": "Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr.",
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"raw_pages": "14103-12",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Withers-Ward ES",
"Mueller TD",
"Chen IS",
"Feigon J."
],
"DOI_URL": "http://dx.doi.org/10.1021/bi0017071"
},
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"volume": "9",
"issue": null,
"year": 2008,
"title": "Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.",
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"raw_pages": "4",
"medline_journal": "BMC Biochem",
"ISO_journal": "BMC Biochem",
"authors": [
"Goh AM",
"Walters KJ",
"Elsasser S",
"Verma R",
"Deshaies RJ",
"Finley D",
"Howley PM."
],
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},
"PUB00056581": {
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"ISBN": null,
"volume": "365",
"issue": "4",
"year": 2007,
"title": "Ubiquitin receptor proteins hHR23a and hPLIC2 interact.",
"URL": null,
"raw_pages": "1093-101",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Kang Y",
"Zhang N",
"Koepp DM",
"Walters KJ."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2006.10.056"
},
"PUB00108651": {
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"volume": "8",
"issue": "4",
"year": 2009,
"title": "The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation.",
"URL": null,
"raw_pages": "449-60",
"medline_journal": "DNA Repair (Amst)",
"ISO_journal": "DNA Repair (Amst)",
"authors": [
"Dantuma NP",
"Heinen C",
"Hoogstraten D."
],
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"PUB00108630": {
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"ISBN": null,
"volume": "13",
"issue": "8",
"year": 1994,
"title": "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.",
"URL": null,
"raw_pages": "1831-43",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J",
"authors": [
"Masutani C",
"Sugasawa K",
"Yanagisawa J",
"Sonoyama T",
"Ui M",
"Enomoto T",
"Takio K",
"Tanaka K",
"van der Spek PJ",
"Bootsma D."
],
"DOI_URL": null
},
"PUB00108622": {
"PMID": 15949443,
"ISBN": null,
"volume": "18",
"issue": "6",
"year": 2005,
"title": "Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.",
"URL": null,
"raw_pages": "687-98",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol Cell",
"authors": [
"Varadan R",
"Assfalg M",
"Raasi S",
"Pickart C",
"Fushman D."
],
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},
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"volume": "274",
"issue": "39",
"year": 1999,
"title": "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.",
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"raw_pages": "28019-25",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Hiyama H",
"Yokoi M",
"Masutani C",
"Sugasawa K",
"Maekawa T",
"Tanaka K",
"Hoeijmakers JH",
"Hanaoka F."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.274.39.28019"
},
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"volume": "285",
"issue": "26",
"year": 2010,
"title": "The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.",
"URL": null,
"raw_pages": "20390-8",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Hanzelmann P",
"Stingele J",
"Hofmann K",
"Schindelin H",
"Raasi S."
],
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},
"PUB00031529": {
"PMID": 15322280,
"ISBN": null,
"volume": "13",
"issue": "9",
"year": 2004,
"title": "Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction.",
"URL": null,
"raw_pages": "2370-7",
"medline_journal": "Protein Sci",
"ISO_journal": "Protein Sci.",
"authors": [
"Kamionka M",
"Feigon J."
],
"DOI_URL": "http://dx.doi.org/10.1110/ps.04824304"
},
"PUB00108626": {
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"volume": "42",
"issue": "46",
"year": 2003,
"title": "Ubiquitin recognition by the DNA repair protein hHR23a.",
"URL": null,
"raw_pages": "13529-35",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Wang Q",
"Goh AM",
"Howley PM",
"Walters KJ."
],
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"PUB00108623": {
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"volume": "5",
"issue": "6",
"year": 2010,
"title": "HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.",
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"raw_pages": "e11371",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS One",
"authors": [
"Li G",
"Elder RT",
"Dubrovsky L",
"Liang D",
"Pushkarsky T",
"Chiu K",
"Fan T",
"Sire J",
"Bukrinsky M",
"Zhao RY."
],
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},
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"PMID": 9371639,
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"volume": "71",
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"year": 1997,
"title": "Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.",
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"raw_pages": "9732-42",
"medline_journal": "J Virol",
"ISO_journal": "J Virol",
"authors": [
"Withers-Ward ES",
"Jowett JB",
"Stewart SA",
"Xie YM",
"Garfinkel A",
"Shibagaki Y",
"Chow SA",
"Shah N",
"Hanaoka F",
"Sawitz DG",
"Armstrong RW",
"Souza LM",
"Chen IS."
],
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"PUB00108652": {
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"year": 2011,
"title": "The crystal structure of the ubiquitin-like (UbL) domain of human homologue A of Rad23 (hHR23A) protein.",
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"medline_journal": "Protein Eng Des Sel",
"ISO_journal": "Protein Eng Des Sel",
"authors": [
"Chen YW",
"Tajima T",
"Agrawal S."
],
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},
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"volume": "100",
"issue": "22",
"year": 2003,
"title": "DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a.",
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"raw_pages": "12694-9",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Walters KJ",
"Lech PJ",
"Goh AM",
"Wang Q",
"Howley PM."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.1634989100"
},
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"ISBN": null,
"volume": "9",
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"year": 2000,
"title": "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.",
"URL": null,
"raw_pages": "1795-803",
"medline_journal": "Hum Mol Genet",
"ISO_journal": "Hum Mol Genet",
"authors": [
"Wang G",
"Sawai N",
"Kotliarova S",
"Kanazawa I",
"Nukina N."
],
"DOI_URL": null
}
},
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"name": "Ubl1_cv_Nsp3_N-like"
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"is_llm": false,
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"representative_structure": {
"accession": "2wyq",
"name": "THE CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE (UBL) DOMAIN OF HHR23A (HUMAN HOMOLOGUE A OF RAD23)"
}
}
}
