"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"cd17126"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 601, 'pathways': 0, 'proteins': 601, 'proteomes': 283, 'sets': 1, 'structural_models': {'alphafold': 541, 'bfvd': 0}, 'structures': 4, 'taxa': 1056}"	"{}"	"[{'text': '<p>HR23A, also termed RAD23A, is a DNA repair protein that binds to 19S subunit of the 26S proteasome and shuttles ubiquitinated proteins to the proteasome for degradation, which is required for efficient nucleotide excision repair (NER), a primary mechanism for removing UV-induced DNA lesions. HR23A also plays a critical role in the interaction of HIV-1 viral protein R (Vpr) with the proteasome, especially facilitating Vpr to promote protein poly-ubiquitination. HR23A contains an N-terminal ubiquitin-like (Ubl) domain that binds proteasomes and two C-terminal ubiquitin-associated (UBA) domains that bind ubiquitin or multi-ubiquitinated substrates. In addition, it has a XPC protein-binding domain that might be necessary for its efficient NER function. [[cite:PUB00108617], [cite:PUB00007089], [cite:PUB00108652], [cite:PUB00108621], [cite:PUB00108622], [cite:PUB00031529], [cite:PUB00029556], [cite:PUB00029780], [cite:PUB00003958], [cite:PUB00108623], [cite:PUB00108624], [cite:PUB00056581], [cite:PUB00108625], [cite:PUB00091873], [cite:PUB00019036], [cite:PUB00108626], [cite:PUB00108627], [cite:PUB00020522], [cite:PUB00108628], [cite:PUB00108629], [cite:PUB00108630], [cite:PUB00024785], [cite:PUB00108618], [cite:PUB00108651]]</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	""	False	False	False	"{'PUB00019036': {'PMID': 12643283, 'ISBN': None, 'volume': '278', 'issue': '11', 'year': 2003, 'title': 'Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains.', 'URL': None, 'raw_pages': '8951-9', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J. Biol. Chem.', 'authors': ['Raasi S', 'Pickart CM.'], 'DOI_URL': 'http://dx.doi.org/10.1074/jbc.M212841200'}, 'PUB00108621': {'PMID': 19724136, 'ISBN': None, 'volume': '65', 'issue': 'Pt 9', 'year': 2009, 'title': 'Crystallization and preliminary X-ray diffraction studies of the ubiquitin-like (UbL) domain of the human homologue A of Rad23 (hHR23A) protein.', 'URL': None, 'raw_pages': '930-2', 'medline_journal': 'Acta Crystallogr Sect F Struct Biol Cryst Commun', 'ISO_journal': 'Acta Crystallogr Sect F Struct Biol Cryst Commun', 'authors': ['Chen YW', 'Tajima T', 'Rees M', 'Garcia-Maya M.'], 'DOI_URL': None}, 'PUB00091873': {'PMID': 15321727, 'ISBN': None, 'volume': '341', 'issue': '5', 'year': 2004, 'title': 'Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A.', 'URL': None, 'raw_pages': '1367-79', 'medline_journal': 'J Mol Biol', 'ISO_journal': 'J. Mol. Biol.', 'authors': ['Raasi S', 'Orlov I', 'Fleming KG', 'Pickart CM.'], 'DOI_URL': 'https://doi.org/10.1016/j.jmb.2004.06.057'}, 'PUB00007089': {'PMID': 12079361, 'ISBN': None, 'volume': '319', 'issue': '5', 'year': 2002, 'title': 'Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions.', 'URL': None, 'raw_pages': '1243-55', 'medline_journal': 'J Mol Biol', 'ISO_journal': 'J. Mol. Biol.', 'authors': ['Mueller TD', 'Feigon J.'], 'DOI_URL': 'http://dx.doi.org/10.1016/S0022-2836(02)00302-9'}, 'PUB00108625': {'PMID': 16712842, 'ISBN': None, 'volume': '580', 'issue': '14', 'year': 2006, 'title': 'Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.', 'URL': None, 'raw_pages': '3401-8', 'medline_journal': 'FEBS Lett', 'ISO_journal': 'FEBS Lett', 'authors': ['Chen L', 'Madura K.'], 'DOI_URL': None}, 'PUB00003958': {'PMID': 9846873, 'ISBN': None, 'volume': '5', 'issue': '12', 'year': 1998, 'title': 'Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr.', 'URL': None, 'raw_pages': '1042-7', 'medline_journal': 'Nat Struct Biol', 'ISO_journal': 'Nat. Struct. Biol.', 'authors': ['Dieckmann T', 'Withers-Ward ES', 'Jarosinski MA', 'Liu CF', 'Chen IS', 'Feigon J.'], 'DOI_URL': 'http://dx.doi.org/10.1038/4220'}, 'PUB00108628': {'PMID': 9372924, 'ISBN': None, 'volume': '17', 'issue': '12', 'year': 1997, 'title': 'Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.', 'URL': None, 'raw_pages': '6924-31', 'medline_journal': 'Mol Cell Biol', 'ISO_journal': 'Mol Cell Biol', 'authors': ['Sugasawa K', 'Ng JM', 'Masutani C', 'Maekawa T', 'Uchida A', 'van der Spek PJ', 'Eker AP', 'Rademakers S', 'Visser C', 'Aboussekhra A', 'Wood RD', 'Hanaoka F', 'Bootsma D', 'Hoeijmakers JH.'], 'DOI_URL': None}, 'PUB00108617': {'PMID': 25311859, 'ISBN': None, 'volume': '426', 'issue': '24', 'year': 2014, 'title': 'Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.', 'URL': None, 'raw_pages': '4049-4060', 'medline_journal': 'J Mol Biol', 'ISO_journal': 'J Mol Biol', 'authors': ['Liang RY', 'Chen L', 'Ko BT', 'Shen YH', 'Li YT', 'Chen BR', 'Lin KT', 'Madura K', 'Chuang SM.'], 'DOI_URL': None}, 'PUB00029780': {'PMID': 12970176, 'ISBN': None, 'volume': '22', 'issue': '18', 'year': 2003, 'title': 'Structural determinants for the binding of ubiquitin-like domains to the proteasome.', 'URL': None, 'raw_pages': '4634-45', 'medline_journal': 'EMBO J', 'ISO_journal': 'EMBO J.', 'authors': ['Mueller TD', 'Feigon J.'], 'DOI_URL': 'http://dx.doi.org/10.1093/emboj/cdg467'}, 'PUB00024785': {'PMID': 11087358, 'ISBN': None, 'volume': '39', 'issue': '46', 'year': 2000, 'title': 'Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr.', 'URL': None, 'raw_pages': '14103-12', 'medline_journal': 'Biochemistry', 'ISO_journal': 'Biochemistry', 'authors': ['Withers-Ward ES', 'Mueller TD', 'Chen IS', 'Feigon J.'], 'DOI_URL': 'http://dx.doi.org/10.1021/bi0017071'}, 'PUB00108624': {'PMID': 18234089, 'ISBN': None, 'volume': '9', 'issue': None, 'year': 2008, 'title': 'Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.', 'URL': None, 'raw_pages': '4', 'medline_journal': 'BMC Biochem', 'ISO_journal': 'BMC Biochem', 'authors': ['Goh AM', 'Walters KJ', 'Elsasser S', 'Verma R', 'Deshaies RJ', 'Finley D', 'Howley PM.'], 'DOI_URL': None}, 'PUB00056581': {'PMID': 17098253, 'ISBN': None, 'volume': '365', 'issue': '4', 'year': 2007, 'title': 'Ubiquitin receptor proteins hHR23a and hPLIC2 interact.', 'URL': None, 'raw_pages': '1093-101', 'medline_journal': 'J Mol Biol', 'ISO_journal': 'J. Mol. Biol.', 'authors': ['Kang Y', 'Zhang N', 'Koepp DM', 'Walters KJ.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.jmb.2006.10.056'}, 'PUB00108651': {'PMID': 19223247, 'ISBN': None, 'volume': '8', 'issue': '4', 'year': 2009, 'title': 'The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation.', 'URL': None, 'raw_pages': '449-60', 'medline_journal': 'DNA Repair (Amst)', 'ISO_journal': 'DNA Repair (Amst)', 'authors': ['Dantuma NP', 'Heinen C', 'Hoogstraten D.'], 'DOI_URL': None}, 'PUB00108630': {'PMID': 8168482, 'ISBN': None, 'volume': '13', 'issue': '8', 'year': 1994, 'title': 'Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.', 'URL': None, 'raw_pages': '1831-43', 'medline_journal': 'EMBO J', 'ISO_journal': 'EMBO J', 'authors': ['Masutani C', 'Sugasawa K', 'Yanagisawa J', 'Sonoyama T', 'Ui M', 'Enomoto T', 'Takio K', 'Tanaka K', 'van der Spek PJ', 'Bootsma D.'], 'DOI_URL': None}, 'PUB00108622': {'PMID': 15949443, 'ISBN': None, 'volume': '18', 'issue': '6', 'year': 2005, 'title': 'Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.', 'URL': None, 'raw_pages': '687-98', 'medline_journal': 'Mol Cell', 'ISO_journal': 'Mol Cell', 'authors': ['Varadan R', 'Assfalg M', 'Raasi S', 'Pickart C', 'Fushman D.'], 'DOI_URL': None}, 'PUB00020522': {'PMID': 10488153, 'ISBN': None, 'volume': '274', 'issue': '39', 'year': 1999, 'title': 'Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.', 'URL': None, 'raw_pages': '28019-25', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J. Biol. Chem.', 'authors': ['Hiyama H', 'Yokoi M', 'Masutani C', 'Sugasawa K', 'Maekawa T', 'Tanaka K', 'Hoeijmakers JH', 'Hanaoka F.'], 'DOI_URL': 'http://dx.doi.org/10.1074/jbc.274.39.28019'}, 'PUB00108618': {'PMID': 20427284, 'ISBN': None, 'volume': '285', 'issue': '26', 'year': 2010, 'title': 'The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.', 'URL': None, 'raw_pages': '20390-8', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J Biol Chem', 'authors': ['Hanzelmann P', 'Stingele J', 'Hofmann K', 'Schindelin H', 'Raasi S.'], 'DOI_URL': None}, 'PUB00031529': {'PMID': 15322280, 'ISBN': None, 'volume': '13', 'issue': '9', 'year': 2004, 'title': 'Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction.', 'URL': None, 'raw_pages': '2370-7', 'medline_journal': 'Protein Sci', 'ISO_journal': 'Protein Sci.', 'authors': ['Kamionka M', 'Feigon J.'], 'DOI_URL': 'http://dx.doi.org/10.1110/ps.04824304'}, 'PUB00108626': {'PMID': 14621999, 'ISBN': None, 'volume': '42', 'issue': '46', 'year': 2003, 'title': 'Ubiquitin recognition by the DNA repair protein hHR23a.', 'URL': None, 'raw_pages': '13529-35', 'medline_journal': 'Biochemistry', 'ISO_journal': 'Biochemistry', 'authors': ['Wang Q', 'Goh AM', 'Howley PM', 'Walters KJ.'], 'DOI_URL': None}, 'PUB00108623': {'PMID': 20614012, 'ISBN': None, 'volume': '5', 'issue': '6', 'year': 2010, 'title': 'HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.', 'URL': None, 'raw_pages': 'e11371', 'medline_journal': 'PLoS One', 'ISO_journal': 'PLoS One', 'authors': ['Li G', 'Elder RT', 'Dubrovsky L', 'Liang D', 'Pushkarsky T', 'Chiu K', 'Fan T', 'Sire J', 'Bukrinsky M', 'Zhao RY.'], 'DOI_URL': None}, 'PUB00108629': {'PMID': 9371639, 'ISBN': None, 'volume': '71', 'issue': '12', 'year': 1997, 'title': 'Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.', 'URL': None, 'raw_pages': '9732-42', 'medline_journal': 'J Virol', 'ISO_journal': 'J Virol', 'authors': ['Withers-Ward ES', 'Jowett JB', 'Stewart SA', 'Xie YM', 'Garfinkel A', 'Shibagaki Y', 'Chow SA', 'Shah N', 'Hanaoka F', 'Sawitz DG', 'Armstrong RW', 'Souza LM', 'Chen IS.'], 'DOI_URL': None}, 'PUB00108652': {'PMID': 21047872, 'ISBN': None, 'volume': '24', 'issue': '1-2', 'year': 2011, 'title': 'The crystal structure of the ubiquitin-like (UbL) domain of human homologue A of Rad23 (hHR23A) protein.', 'URL': None, 'raw_pages': '131-8', 'medline_journal': 'Protein Eng Des Sel', 'ISO_journal': 'Protein Eng Des Sel', 'authors': ['Chen YW', 'Tajima T', 'Agrawal S.'], 'DOI_URL': None}, 'PUB00029556': {'PMID': 14557549, 'ISBN': None, 'volume': '100', 'issue': '22', 'year': 2003, 'title': 'DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a.', 'URL': None, 'raw_pages': '12694-9', 'medline_journal': 'Proc Natl Acad Sci U S A', 'ISO_journal': 'Proc. Natl. Acad. Sci. U.S.A.', 'authors': ['Walters KJ', 'Lech PJ', 'Goh AM', 'Wang Q', 'Howley PM.'], 'DOI_URL': 'http://dx.doi.org/10.1073/pnas.1634989100'}, 'PUB00108627': {'PMID': 10915768, 'ISBN': None, 'volume': '9', 'issue': '12', 'year': 2000, 'title': 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.', 'URL': None, 'raw_pages': '1795-803', 'medline_journal': 'Hum Mol Genet', 'ISO_journal': 'Hum Mol Genet', 'authors': ['Wang G', 'Sawai N', 'Kotliarova S', 'Kanazawa I', 'Nukina N.'], 'DOI_URL': None}}"	""	"{'name': 'ubiquitin-like (Ubl) domain found in UV excision repair protein RAD23 homolog A (HR23A)', 'short': 'Ubl_HR23A'}"	""	"{'accession': '2wyq', 'name': 'THE CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE (UBL) DOMAIN OF HHR23A (HUMAN HOMOLOGUE A OF RAD23)'}"	"{'accession': 'cl28922', 'name': 'Ubl1_cv_Nsp3_N-like'}"	"cdd"	"domain"	""