{"metadata":{"accession":"cd17126","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"ubiquitin-like (Ubl) domain found in UV excision repair protein RAD23 homolog A (HR23A)","short":"Ubl_HR23A"},"description":[{"text":"<p>HR23A, also termed RAD23A, is a DNA repair protein that binds to 19S subunit of the 26S proteasome and shuttles ubiquitinated proteins to the proteasome for degradation, which is required for efficient nucleotide excision repair (NER), a primary mechanism for removing UV-induced DNA lesions. HR23A also plays a critical role in the interaction of HIV-1 viral protein R (Vpr) with the proteasome, especially facilitating Vpr to promote protein poly-ubiquitination. HR23A contains an N-terminal ubiquitin-like (Ubl) domain that binds proteasomes and two C-terminal ubiquitin-associated (UBA) domains that bind ubiquitin or multi-ubiquitinated substrates. In addition, it has a XPC protein-binding domain that might be necessary for its efficient NER function. [[cite:PUB00108617], [cite:PUB00007089], [cite:PUB00108652], [cite:PUB00108621], [cite:PUB00108622], [cite:PUB00031529], [cite:PUB00029556], [cite:PUB00029780], [cite:PUB00003958], [cite:PUB00108623], [cite:PUB00108624], [cite:PUB00056581], [cite:PUB00108625], [cite:PUB00091873], [cite:PUB00019036], [cite:PUB00108626], [cite:PUB00108627], [cite:PUB00020522], [cite:PUB00108628], [cite:PUB00108629], [cite:PUB00108630], [cite:PUB00024785], [cite:PUB00108618], [cite:PUB00108651]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00019036":{"PMID":12643283,"ISBN":null,"volume":"278","issue":"11","year":2003,"title":"Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains.","URL":null,"raw_pages":"8951-9","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. 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Biol.","authors":["Raasi S","Orlov I","Fleming KG","Pickart CM."],"DOI_URL":"https://doi.org/10.1016/j.jmb.2004.06.057"},"PUB00007089":{"PMID":12079361,"ISBN":null,"volume":"319","issue":"5","year":2002,"title":"Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions.","URL":null,"raw_pages":"1243-55","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. 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Biol.","authors":["Dieckmann T","Withers-Ward ES","Jarosinski MA","Liu CF","Chen IS","Feigon J."],"DOI_URL":"http://dx.doi.org/10.1038/4220"},"PUB00108628":{"PMID":9372924,"ISBN":null,"volume":"17","issue":"12","year":1997,"title":"Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.","URL":null,"raw_pages":"6924-31","medline_journal":"Mol Cell Biol","ISO_journal":"Mol Cell Biol","authors":["Sugasawa K","Ng JM","Masutani C","Maekawa T","Uchida A","van der Spek PJ","Eker AP","Rademakers S","Visser C","Aboussekhra A","Wood RD","Hanaoka F","Bootsma D","Hoeijmakers JH."],"DOI_URL":null},"PUB00108617":{"PMID":25311859,"ISBN":null,"volume":"426","issue":"24","year":2014,"title":"Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.","URL":null,"raw_pages":"4049-4060","medline_journal":"J Mol Biol","ISO_journal":"J Mol Biol","authors":["Liang RY","Chen L","Ko BT","Shen YH","Li YT","Chen BR","Lin KT","Madura K","Chuang SM."],"DOI_URL":null},"PUB00029780":{"PMID":12970176,"ISBN":null,"volume":"22","issue":"18","year":2003,"title":"Structural determinants for the binding of ubiquitin-like domains to the proteasome.","URL":null,"raw_pages":"4634-45","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Mueller TD","Feigon J."],"DOI_URL":"http://dx.doi.org/10.1093/emboj/cdg467"},"PUB00024785":{"PMID":11087358,"ISBN":null,"volume":"39","issue":"46","year":2000,"title":"Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr.","URL":null,"raw_pages":"14103-12","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Withers-Ward ES","Mueller TD","Chen IS","Feigon J."],"DOI_URL":"http://dx.doi.org/10.1021/bi0017071"},"PUB00108624":{"PMID":18234089,"ISBN":null,"volume":"9","issue":null,"year":2008,"title":"Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.","URL":null,"raw_pages":"4","medline_journal":"BMC Biochem","ISO_journal":"BMC Biochem","authors":["Goh AM","Walters KJ","Elsasser S","Verma R","Deshaies RJ","Finley D","Howley PM."],"DOI_URL":null},"PUB00056581":{"PMID":17098253,"ISBN":null,"volume":"365","issue":"4","year":2007,"title":"Ubiquitin receptor proteins hHR23a and hPLIC2 interact.","URL":null,"raw_pages":"1093-101","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Kang Y","Zhang N","Koepp DM","Walters KJ."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2006.10.056"},"PUB00108651":{"PMID":19223247,"ISBN":null,"volume":"8","issue":"4","year":2009,"title":"The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation.","URL":null,"raw_pages":"449-60","medline_journal":"DNA Repair (Amst)","ISO_journal":"DNA Repair (Amst)","authors":["Dantuma NP","Heinen C","Hoogstraten D."],"DOI_URL":null},"PUB00108630":{"PMID":8168482,"ISBN":null,"volume":"13","issue":"8","year":1994,"title":"Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.","URL":null,"raw_pages":"1831-43","medline_journal":"EMBO J","ISO_journal":"EMBO J","authors":["Masutani C","Sugasawa K","Yanagisawa J","Sonoyama T","Ui M","Enomoto T","Takio K","Tanaka K","van der Spek PJ","Bootsma D."],"DOI_URL":null},"PUB00108622":{"PMID":15949443,"ISBN":null,"volume":"18","issue":"6","year":2005,"title":"Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.","URL":null,"raw_pages":"687-98","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Varadan R","Assfalg M","Raasi S","Pickart C","Fushman D."],"DOI_URL":null},"PUB00020522":{"PMID":10488153,"ISBN":null,"volume":"274","issue":"39","year":1999,"title":"Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.","URL":null,"raw_pages":"28019-25","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Hiyama H","Yokoi M","Masutani C","Sugasawa K","Maekawa T","Tanaka K","Hoeijmakers JH","Hanaoka F."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.274.39.28019"},"PUB00108618":{"PMID":20427284,"ISBN":null,"volume":"285","issue":"26","year":2010,"title":"The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.","URL":null,"raw_pages":"20390-8","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Hanzelmann P","Stingele J","Hofmann K","Schindelin H","Raasi S."],"DOI_URL":null},"PUB00031529":{"PMID":15322280,"ISBN":null,"volume":"13","issue":"9","year":2004,"title":"Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction.","URL":null,"raw_pages":"2370-7","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Kamionka M","Feigon J."],"DOI_URL":"http://dx.doi.org/10.1110/ps.04824304"},"PUB00108626":{"PMID":14621999,"ISBN":null,"volume":"42","issue":"46","year":2003,"title":"Ubiquitin recognition by the DNA repair protein hHR23a.","URL":null,"raw_pages":"13529-35","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Wang Q","Goh AM","Howley PM","Walters KJ."],"DOI_URL":null},"PUB00108623":{"PMID":20614012,"ISBN":null,"volume":"5","issue":"6","year":2010,"title":"HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.","URL":null,"raw_pages":"e11371","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Li G","Elder RT","Dubrovsky L","Liang D","Pushkarsky T","Chiu K","Fan T","Sire J","Bukrinsky M","Zhao RY."],"DOI_URL":null},"PUB00108629":{"PMID":9371639,"ISBN":null,"volume":"71","issue":"12","year":1997,"title":"Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.","URL":null,"raw_pages":"9732-42","medline_journal":"J Virol","ISO_journal":"J Virol","authors":["Withers-Ward ES","Jowett JB","Stewart SA","Xie YM","Garfinkel A","Shibagaki Y","Chow SA","Shah N","Hanaoka F","Sawitz DG","Armstrong RW","Souza LM","Chen IS."],"DOI_URL":null},"PUB00108652":{"PMID":21047872,"ISBN":null,"volume":"24","issue":"1-2","year":2011,"title":"The crystal structure of the ubiquitin-like (UbL) domain of human homologue A of Rad23 (hHR23A) protein.","URL":null,"raw_pages":"131-8","medline_journal":"Protein Eng Des Sel","ISO_journal":"Protein Eng Des Sel","authors":["Chen YW","Tajima T","Agrawal S."],"DOI_URL":null},"PUB00029556":{"PMID":14557549,"ISBN":null,"volume":"100","issue":"22","year":2003,"title":"DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a.","URL":null,"raw_pages":"12694-9","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Walters KJ","Lech PJ","Goh AM","Wang Q","Howley PM."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1634989100"},"PUB00108627":{"PMID":10915768,"ISBN":null,"volume":"9","issue":"12","year":2000,"title":"Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.","URL":null,"raw_pages":"1795-803","medline_journal":"Hum Mol Genet","ISO_journal":"Hum Mol Genet","authors":["Wang G","Sawai N","Kotliarova S","Kanazawa I","Nukina N."],"DOI_URL":null}},"set_info":{"accession":"cl28922","name":"Ubl1_cv_Nsp3_N-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":601,"pathways":0,"proteins":601,"proteomes":283,"sets":1,"structural_models":{"alphafold":541,"bfvd":0},"structures":4,"taxa":1056},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2wyq","name":"THE CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE (UBL) DOMAIN OF HHR23A (HUMAN HOMOLOGUE A OF RAD23)"}}}