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{
"metadata": {
"accession": "cd12254",
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"name": {
"name": "RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins",
"short": "RRM_hnRNPH_ESRPs_RBM12_like"
},
"description": [
{
"text": "<p>The family includes RRM domains in the hnRNP H protein family, G-rich sequence factor 1 (GRSF-1), ESRPs (also termed RBM35), Drosophila Fusilli, RBM12 (also termed SWAN), RBM12B, RBM19 (also termed RBD-1) and similar proteins. The hnRNP H protein family includes hnRNP H (also termed mcs94-1), hnRNP H2 (also termed FTP-3 or hnRNP H'), hnRNP F and hnRNP H3 (also termed hnRNP 2H9), which represent a group of nuclear RNA binding proteins that are involved in pre-mRNA processing. GRSF-1 is a cytoplasmic poly(A)+ mRNA binding protein which interacts with RNA in a G-rich element-dependent manner. It may function in RNA packaging, stabilization of RNA secondary structure, or other macromolecular interactions. ESRP1 (also termed RBM35A) and ESRP2 (also termed RBM35B) are epithelial-specific RNA binding proteins that promote splicing of the epithelial variant of fibroblast growth factor receptor 2 (FGFR2), ENAH (also termed hMena), CD44 and CTNND1 (also termed p120-Catenin) transcripts. Fusilli shows high sequence homology to ESRPs. It can regulate endogenous FGFR2 splicing and functions as a splicing factor. The biological roles of both, RBM12 and RBM12B, remain unclear. RBM19 is a nucleolar protein conserved in eukaryotes. It is involved in ribosome biogenesis by processing rRNA. In addition, it is essential for preimplantation development. Members in this family contain 2~6 conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). [[cite:PUB00034497], [cite:PUB00112793], [cite:PUB00048989], [cite:PUB00048661], [cite:PUB00112797], [cite:PUB00035461], [cite:PUB00039244], [cite:PUB00041520], [cite:PUB00040418], [cite:PUB00041398], [cite:PUB00032930], [cite:PUB00112798], [cite:PUB00112799], [cite:PUB00112800], [cite:PUB00112801], [cite:PUB00079469], [cite:PUB00079470]]</p>",
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"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
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"Shamoo Y",
"Abdul-Manan N",
"Williams KR."
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"Auweter SD",
"Fasan R",
"Reymond L",
"Underwood JG",
"Black DL",
"Pitsch S",
"Allain FH."
],
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"Deka P",
"Rajan PK",
"Perez-Canadillas JM",
"Varani G."
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"medline_journal": "Curr Opin Struct Biol",
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"authors": [
"Clery A",
"Blatter M",
"Allain FH."
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"Corsini L",
"Bonnal S",
"Bonna S",
"Basquin J",
"Hothorn M",
"Scheffzek K",
"Valcarcel J",
"Sattler M."
],
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"medline_journal": "FEBS J",
"ISO_journal": "FEBS J.",
"authors": [
"Maris C",
"Dominguez C",
"Allain FH."
],
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"title": "Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.",
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"medline_journal": "Wiley Interdiscip Rev RNA",
"ISO_journal": "Wiley Interdiscip Rev RNA",
"authors": [
"Muto Y",
"Yokoyama S."
],
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"title": "Dynamics in multi-domain protein recognition of RNA.",
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"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Mackereth CD",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.sbi.2012.03.013"
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"title": "SRPrises in RNA-protein recognition.",
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"medline_journal": "Structure",
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"authors": [
"Rupert PB",
"Ferre-D'amare AR."
],
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"issue": "13",
"year": 2006,
"title": "NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.",
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"raw_pages": "3634-45",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Dominguez C",
"Allain FH."
],
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"authors": [
"Oberstrass FC",
"Auweter SD",
"Erat M",
"Hargous Y",
"Henning A",
"Wenter P",
"Reymond L",
"Amir-Ahmady B",
"Pitsch S",
"Black DL",
"Allain FH."
],
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"title": "Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.",
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"authors": [
"Hargous Y",
"Hautbergue GM",
"Tintaru AM",
"Skrisovska L",
"Golovanov AP",
"Stevenin J",
"Lian LY",
"Wilson SA",
"Allain FH."
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"title": "A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain.",
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"Rideau AP",
"Gooding C",
"Simpson PJ",
"Monie TP",
"Lorenz M",
"Huttelmaier S",
"Singer RH",
"Matthews S",
"Curry S",
"Smith CW."
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"title": "Crystal structure of a core spliceosomal protein interface.",
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"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Schellenberg MJ",
"Edwards RA",
"Ritchie DB",
"Kent OA",
"Golas MM",
"Stark H",
"Luhrmann R",
"Glover JN",
"MacMillan AM."
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"title": "New features in RNA recognition: a Tat-TAR complex.",
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"Wemmer DE."
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"title": "Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition.",
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"authors": [
"Crichlow GV",
"Zhou H",
"Hsiao HH",
"Frederick KB",
"Debrosse M",
"Yang Y",
"Folta-Stogniew EJ",
"Chung HJ",
"Fan C",
"De la Cruz EM",
"Levens D",
"Lolis E",
"Braddock D."
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"issue": "9",
"year": 1999,
"title": "Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA.",
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"raw_pages": "1102-15",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev.",
"authors": [
"Ding J",
"Hayashi MK",
"Zhang Y",
"Manche L",
"Krainer AR",
"Xu RM."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=10323862&action=stream&blobtype=pdf"
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"name": "Crystal structure of Glorund qRRM1 domain"
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}
