{"metadata":{"accession":"cd12254","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins","short":"RRM_hnRNPH_ESRPs_RBM12_like"},"description":[{"text":"<p>The family includes RRM domains in the hnRNP H protein family, G-rich sequence factor 1 (GRSF-1), ESRPs (also termed RBM35), Drosophila Fusilli, RBM12 (also termed SWAN), RBM12B, RBM19 (also termed RBD-1) and similar proteins. The hnRNP H protein family includes hnRNP H (also termed mcs94-1), hnRNP H2 (also termed FTP-3 or hnRNP H'), hnRNP F and hnRNP H3 (also termed hnRNP 2H9), which represent a group of nuclear RNA binding proteins that are involved in pre-mRNA processing. GRSF-1 is a cytoplasmic poly(A)+ mRNA binding protein which interacts with RNA in a G-rich element-dependent manner. It may function in RNA packaging, stabilization of RNA secondary structure, or other macromolecular interactions. ESRP1 (also termed RBM35A) and ESRP2 (also termed RBM35B) are epithelial-specific RNA binding proteins that promote splicing of the epithelial variant of fibroblast growth factor receptor 2 (FGFR2), ENAH (also termed hMena), CD44 and CTNND1 (also termed p120-Catenin) transcripts. Fusilli shows high sequence homology to ESRPs. It can regulate endogenous FGFR2 splicing and functions as a splicing factor. The biological roles of both, RBM12 and RBM12B, remain unclear. RBM19 is a nucleolar protein conserved in eukaryotes. It is involved in ribosome biogenesis by processing rRNA. In addition, it is essential for preimplantation development. Members in this family contain 2~6 conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).  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Not quite.","URL":null,"raw_pages":"290-8","medline_journal":"Curr Opin Struct Biol","ISO_journal":"Curr Opin Struct Biol","authors":["Clery A","Blatter M","Allain FH."],"DOI_URL":null},"PUB00048661":{"PMID":17589525,"ISBN":null,"volume":"14","issue":"7","year":2007,"title":"U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.","URL":null,"raw_pages":"620-9","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Corsini L","Bonnal S","Bonna S","Basquin J","Hothorn M","Scheffzek K","Valcarcel J","Sattler M."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb1260"},"PUB00034497":{"PMID":15853797,"ISBN":null,"volume":"272","issue":"9","year":2005,"title":"The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression.","URL":null,"raw_pages":"2118-31","medline_journal":"FEBS J","ISO_journal":"FEBS J.","authors":["Maris C","Dominguez C","Allain FH."],"DOI_URL":"http://dx.doi.org/10.1111/j.1742-4658.2005.04653.x"},"PUB00079470":{"PMID":22278943,"ISBN":null,"volume":"3","issue":"2","year":2012,"title":"Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.","URL":null,"raw_pages":"229-46","medline_journal":"Wiley Interdiscip Rev RNA","ISO_journal":"Wiley Interdiscip Rev RNA","authors":["Muto Y","Yokoyama S."],"DOI_URL":"http://dx.doi.org/10.1002/wrna.1107"},"PUB00079469":{"PMID":22516180,"ISBN":null,"volume":"22","issue":"3","year":2012,"title":"Dynamics in multi-domain protein recognition of RNA.","URL":null,"raw_pages":"287-96","medline_journal":"Curr Opin Struct Biol","ISO_journal":"Curr. Opin. Struct. Biol.","authors":["Mackereth CD","Sattler M."],"DOI_URL":"http://dx.doi.org/10.1016/j.sbi.2012.03.013"},"PUB00112801":{"PMID":10896472,"ISBN":null,"volume":"8","issue":"5","year":2000,"title":"SRPrises in RNA-protein recognition.","URL":null,"raw_pages":"R99-104","medline_journal":"Structure","ISO_journal":"Structure","authors":["Rupert PB","Ferre-D'amare AR."],"DOI_URL":null},"PUB00041398":{"PMID":16885237,"ISBN":null,"volume":"34","issue":"13","year":2006,"title":"NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.","URL":null,"raw_pages":"3634-45","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Dominguez C","Allain FH."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gkl488"},"PUB00039244":{"PMID":16179478,"ISBN":null,"volume":"309","issue":"5743","year":2005,"title":"Structure of PTB bound to RNA: specific binding and implications for splicing regulation.","URL":null,"raw_pages":"2054-7","medline_journal":"Science","ISO_journal":"Science","authors":["Oberstrass FC","Auweter SD","Erat M","Hargous Y","Henning A","Wenter P","Reymond L","Amir-Ahmady B","Pitsch S","Black DL","Allain FH."],"DOI_URL":"http://dx.doi.org/10.1126/science.1114066"},"PUB00041520":{"PMID":17036044,"ISBN":null,"volume":"25","issue":"21","year":2006,"title":"Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.","URL":null,"raw_pages":"5126-37","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Hargous Y","Hautbergue GM","Tintaru AM","Skrisovska L","Golovanov AP","Stevenin J","Lian LY","Wilson SA","Allain FH."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7601385"},"PUB00112797":{"PMID":16936729,"ISBN":null,"volume":"13","issue":"9","year":2006,"title":"A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain.","URL":null,"raw_pages":"839-48","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Rideau AP","Gooding C","Simpson PJ","Monie TP","Lorenz M","Huttelmaier S","Singer RH","Matthews S","Curry S","Smith CW."],"DOI_URL":null},"PUB00035461":{"PMID":16432215,"ISBN":null,"volume":"103","issue":"5","year":2006,"title":"Crystal structure of a core spliceosomal protein interface.","URL":null,"raw_pages":"1266-71","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Schellenberg MJ","Edwards RA","Ritchie DB","Kent OA","Golas MM","Stark H","Luhrmann R","Glover JN","MacMillan AM."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0508048103"},"PUB00112799":{"PMID":8807823,"ISBN":null,"volume":"3","issue":"1","year":1996,"title":"New features in RNA recognition: a Tat-TAR complex.","URL":null,"raw_pages":"17-9","medline_journal":"Chem Biol","ISO_journal":"Chem Biol","authors":["Wemmer DE."],"DOI_URL":null},"PUB00048989":{"PMID":18059478,"ISBN":null,"volume":"27","issue":"1","year":2008,"title":"Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition.","URL":null,"raw_pages":"277-89","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Crichlow GV","Zhou H","Hsiao HH","Frederick KB","Debrosse M","Yang Y","Folta-Stogniew EJ","Chung HJ","Fan C","De la Cruz EM","Levens D","Lolis E","Braddock D."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7601936"},"PUB00032930":{"PMID":10323862,"ISBN":null,"volume":"13","issue":"9","year":1999,"title":"Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA.","URL":null,"raw_pages":"1102-15","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Ding J","Hayashi MK","Zhang Y","Manche L","Krainer AR","Xu RM."],"DOI_URL":"http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=10323862&action=stream&blobtype=pdf"}},"set_info":{"accession":"cl17169","name":"RRM_SF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":6200,"pathways":0,"proteins":3927,"proteomes":1412,"sets":1,"structural_models":{"alphafold":3337,"bfvd":0},"structures":3,"taxa":4593},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5uzg","name":"Crystal structure of Glorund qRRM1 domain"}}}