"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"cd12254"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 6200, 'pathways': 0, 'proteins': 3927, 'proteomes': 1412, 'sets': 1, 'structural_models': {'alphafold': 3337, 'bfvd': 0}, 'structures': 3, 'taxa': 4593}"	"{}"	"[{'text': ""<p>The family includes RRM domains in the hnRNP H protein family, G-rich sequence factor 1 (GRSF-1), ESRPs (also termed RBM35), Drosophila Fusilli, RBM12 (also termed SWAN), RBM12B, RBM19 (also termed RBD-1) and similar proteins. The hnRNP H protein family includes hnRNP H (also termed mcs94-1), hnRNP H2 (also termed FTP-3 or hnRNP H'), hnRNP F and hnRNP H3 (also termed hnRNP 2H9), which represent a group of nuclear RNA binding proteins that are involved in pre-mRNA processing. GRSF-1 is a cytoplasmic poly(A)+ mRNA binding protein which interacts with RNA in a G-rich element-dependent manner. It may function in RNA packaging, stabilization of RNA secondary structure, or other macromolecular interactions. ESRP1 (also termed RBM35A) and ESRP2 (also termed RBM35B) are epithelial-specific RNA binding proteins that promote splicing of the epithelial variant of fibroblast growth factor receptor 2 (FGFR2), ENAH (also termed hMena), CD44 and CTNND1 (also termed p120-Catenin) transcripts. Fusilli shows high sequence homology to ESRPs. It can regulate endogenous FGFR2 splicing and functions as a splicing factor. The biological roles of both, RBM12 and RBM12B, remain unclear. RBM19 is a nucleolar protein conserved in eukaryotes. It is involved in ribosome biogenesis by processing rRNA. In addition, it is essential for preimplantation development. Members in this family contain 2~6 conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).  [[cite:PUB00034497], [cite:PUB00112793], [cite:PUB00048989], [cite:PUB00048661], [cite:PUB00112797], [cite:PUB00035461], [cite:PUB00039244], [cite:PUB00041520], [cite:PUB00040418], [cite:PUB00041398], [cite:PUB00032930], [cite:PUB00112798], [cite:PUB00112799], [cite:PUB00112800], [cite:PUB00112801], [cite:PUB00079469], [cite:PUB00079470]]</p>"", 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	""	False	False	False	"{'PUB00112800': {'PMID': 7535921, 'ISBN': None, 'volume': '23', 'issue': '5', 'year': 1995, 'title': ""Multiple RNA binding domains (RBDs) just don't add up."", 'URL': None, 'raw_pages': '725-8', 'medline_journal': 'Nucleic Acids Res', 'ISO_journal': 'Nucleic Acids Res', 'authors': ['Shamoo Y', 'Abdul-Manan N', 'Williams KR.'], 'DOI_URL': None}, 'PUB00040418': {'PMID': 16362037, 'ISBN': None, 'volume': '25', 'issue': '1', 'year': 2006, 'title': 'Molecular basis of RNA recognition by the human alternative splicing factor Fox-1.', 'URL': None, 'raw_pages': '163-73', 'medline_journal': 'EMBO J', 'ISO_journal': 'EMBO J.', 'authors': ['Auweter SD', 'Fasan R', 'Reymond L', 'Underwood JG', 'Black DL', 'Pitsch S', 'Allain FH.'], 'DOI_URL': 'http://dx.doi.org/10.1038/sj.emboj.7600918'}, 'PUB00112798': {'PMID': 15769465, 'ISBN': None, 'volume': '347', 'issue': '4', 'year': 2005, 'title': 'Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein.', 'URL': None, 'raw_pages': '719-33', 'medline_journal': 'J Mol Biol', 'ISO_journal': 'J Mol Biol', 'authors': ['Deka P', 'Rajan PK', 'Perez-Canadillas JM', 'Varani G.'], 'DOI_URL': None}, 'PUB00112793': {'PMID': 18515081, 'ISBN': None, 'volume': '18', 'issue': '3', 'year': 2008, 'title': 'RNA recognition motifs: boring? Not quite.', 'URL': None, 'raw_pages': '290-8', 'medline_journal': 'Curr Opin Struct Biol', 'ISO_journal': 'Curr Opin Struct Biol', 'authors': ['Clery A', 'Blatter M', 'Allain FH.'], 'DOI_URL': None}, 'PUB00048661': {'PMID': 17589525, 'ISBN': None, 'volume': '14', 'issue': '7', 'year': 2007, 'title': 'U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.', 'URL': None, 'raw_pages': '620-9', 'medline_journal': 'Nat Struct Mol Biol', 'ISO_journal': 'Nat. Struct. Mol. Biol.', 'authors': ['Corsini L', 'Bonnal S', 'Bonna S', 'Basquin J', 'Hothorn M', 'Scheffzek K', 'Valcarcel J', 'Sattler M.'], 'DOI_URL': 'http://dx.doi.org/10.1038/nsmb1260'}, 'PUB00034497': {'PMID': 15853797, 'ISBN': None, 'volume': '272', 'issue': '9', 'year': 2005, 'title': 'The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression.', 'URL': None, 'raw_pages': '2118-31', 'medline_journal': 'FEBS J', 'ISO_journal': 'FEBS J.', 'authors': ['Maris C', 'Dominguez C', 'Allain FH.'], 'DOI_URL': 'http://dx.doi.org/10.1111/j.1742-4658.2005.04653.x'}, 'PUB00079470': {'PMID': 22278943, 'ISBN': None, 'volume': '3', 'issue': '2', 'year': 2012, 'title': 'Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.', 'URL': None, 'raw_pages': '229-46', 'medline_journal': 'Wiley Interdiscip Rev RNA', 'ISO_journal': 'Wiley Interdiscip Rev RNA', 'authors': ['Muto Y', 'Yokoyama S.'], 'DOI_URL': 'http://dx.doi.org/10.1002/wrna.1107'}, 'PUB00079469': {'PMID': 22516180, 'ISBN': None, 'volume': '22', 'issue': '3', 'year': 2012, 'title': 'Dynamics in multi-domain protein recognition of RNA.', 'URL': None, 'raw_pages': '287-96', 'medline_journal': 'Curr Opin Struct Biol', 'ISO_journal': 'Curr. Opin. Struct. Biol.', 'authors': ['Mackereth CD', 'Sattler M.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.sbi.2012.03.013'}, 'PUB00112801': {'PMID': 10896472, 'ISBN': None, 'volume': '8', 'issue': '5', 'year': 2000, 'title': 'SRPrises in RNA-protein recognition.', 'URL': None, 'raw_pages': 'R99-104', 'medline_journal': 'Structure', 'ISO_journal': 'Structure', 'authors': ['Rupert PB', ""Ferre-D'amare AR.""], 'DOI_URL': None}, 'PUB00041398': {'PMID': 16885237, 'ISBN': None, 'volume': '34', 'issue': '13', 'year': 2006, 'title': 'NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.', 'URL': None, 'raw_pages': '3634-45', 'medline_journal': 'Nucleic Acids Res', 'ISO_journal': 'Nucleic Acids Res.', 'authors': ['Dominguez C', 'Allain FH.'], 'DOI_URL': 'http://dx.doi.org/10.1093/nar/gkl488'}, 'PUB00039244': {'PMID': 16179478, 'ISBN': None, 'volume': '309', 'issue': '5743', 'year': 2005, 'title': 'Structure of PTB bound to RNA: specific binding and implications for splicing regulation.', 'URL': None, 'raw_pages': '2054-7', 'medline_journal': 'Science', 'ISO_journal': 'Science', 'authors': ['Oberstrass FC', 'Auweter SD', 'Erat M', 'Hargous Y', 'Henning A', 'Wenter P', 'Reymond L', 'Amir-Ahmady B', 'Pitsch S', 'Black DL', 'Allain FH.'], 'DOI_URL': 'http://dx.doi.org/10.1126/science.1114066'}, 'PUB00041520': {'PMID': 17036044, 'ISBN': None, 'volume': '25', 'issue': '21', 'year': 2006, 'title': 'Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.', 'URL': None, 'raw_pages': '5126-37', 'medline_journal': 'EMBO J', 'ISO_journal': 'EMBO J.', 'authors': ['Hargous Y', 'Hautbergue GM', 'Tintaru AM', 'Skrisovska L', 'Golovanov AP', 'Stevenin J', 'Lian LY', 'Wilson SA', 'Allain FH.'], 'DOI_URL': 'http://dx.doi.org/10.1038/sj.emboj.7601385'}, 'PUB00112797': {'PMID': 16936729, 'ISBN': None, 'volume': '13', 'issue': '9', 'year': 2006, 'title': 'A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain.', 'URL': None, 'raw_pages': '839-48', 'medline_journal': 'Nat Struct Mol Biol', 'ISO_journal': 'Nat Struct Mol Biol', 'authors': ['Rideau AP', 'Gooding C', 'Simpson PJ', 'Monie TP', 'Lorenz M', 'Huttelmaier S', 'Singer RH', 'Matthews S', 'Curry S', 'Smith CW.'], 'DOI_URL': None}, 'PUB00035461': {'PMID': 16432215, 'ISBN': None, 'volume': '103', 'issue': '5', 'year': 2006, 'title': 'Crystal structure of a core spliceosomal protein interface.', 'URL': None, 'raw_pages': '1266-71', 'medline_journal': 'Proc Natl Acad Sci U S A', 'ISO_journal': 'Proc. Natl. Acad. Sci. U.S.A.', 'authors': ['Schellenberg MJ', 'Edwards RA', 'Ritchie DB', 'Kent OA', 'Golas MM', 'Stark H', 'Luhrmann R', 'Glover JN', 'MacMillan AM.'], 'DOI_URL': 'http://dx.doi.org/10.1073/pnas.0508048103'}, 'PUB00112799': {'PMID': 8807823, 'ISBN': None, 'volume': '3', 'issue': '1', 'year': 1996, 'title': 'New features in RNA recognition: a Tat-TAR complex.', 'URL': None, 'raw_pages': '17-9', 'medline_journal': 'Chem Biol', 'ISO_journal': 'Chem Biol', 'authors': ['Wemmer DE.'], 'DOI_URL': None}, 'PUB00048989': {'PMID': 18059478, 'ISBN': None, 'volume': '27', 'issue': '1', 'year': 2008, 'title': 'Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition.', 'URL': None, 'raw_pages': '277-89', 'medline_journal': 'EMBO J', 'ISO_journal': 'EMBO J.', 'authors': ['Crichlow GV', 'Zhou H', 'Hsiao HH', 'Frederick KB', 'Debrosse M', 'Yang Y', 'Folta-Stogniew EJ', 'Chung HJ', 'Fan C', 'De la Cruz EM', 'Levens D', 'Lolis E', 'Braddock D.'], 'DOI_URL': 'http://dx.doi.org/10.1038/sj.emboj.7601936'}, 'PUB00032930': {'PMID': 10323862, 'ISBN': None, 'volume': '13', 'issue': '9', 'year': 1999, 'title': 'Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA.', 'URL': None, 'raw_pages': '1102-15', 'medline_journal': 'Genes Dev', 'ISO_journal': 'Genes Dev.', 'authors': ['Ding J', 'Hayashi MK', 'Zhang Y', 'Manche L', 'Krainer AR', 'Xu RM.'], 'DOI_URL': 'http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=10323862&action=stream&blobtype=pdf'}}"	""	"{'name': 'RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins', 'short': 'RRM_hnRNPH_ESRPs_RBM12_like'}"	""	"{'accession': '5uzg', 'name': 'Crystal structure of Glorund qRRM1 domain'}"	"{'accession': 'cl17169', 'name': 'RRM_SF'}"	"cdd"	"domain"	""