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{
"metadata": {
"accession": "IPR039095",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0010468",
"name": "regulation of gene expression",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd15609": "PHD finger found in Transcription factor 19 (TCF-19) and similar proteins"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001965",
"name": "Zinc finger, PHD-type",
"type": "Domain",
"children": [
{
"accession": "IPR019787",
"name": "Zinc finger, PHD-finger",
"type": "Domain",
"children": [
{
"accession": "IPR028940",
"name": "Bromodomain adjacent to zinc finger domain protein 2A, PHD zinc finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR031202",
"name": "PHD finger protein 1, PHD finger 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR037373",
"name": "Transcription intermediary factor 1-beta, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037877",
"name": "HMT2C, PHD3",
"type": "Domain",
"children": []
},
{
"accession": "IPR039054",
"name": "Int12, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR039546",
"name": "Jade-1, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR039548",
"name": "JADE2, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039550",
"name": "JADE3, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041947",
"name": "PHF13, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042008",
"name": "BRPF1, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042009",
"name": "BRPF2, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042010",
"name": "ATX1/2, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042011",
"name": "ATX3/4/5, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042014",
"name": "MTF2, PHD domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR042019",
"name": "ING2, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042020",
"name": "ING3, PHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042023",
"name": "KMT2A, PHD domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR042025",
"name": "KMT2A, PHD domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR044075",
"name": "PRKCBP1, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR044104",
"name": "Alfin1-like, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR044133",
"name": "KMT2A, PHD domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR045876",
"name": "Pathogenesis-related homeodomain protein, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR046999",
"name": "KMT2D, PHD5 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047000",
"name": "KMT2D, PHD3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047003",
"name": "KMT2C, PHD4 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047004",
"name": "KMT2C, PHD2 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047005",
"name": "KMT2C, PHD6 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047256",
"name": "Tyrosine-protein kinase BAZ1B, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047426",
"name": "Histone-lysine N-methyltransferase NSD1 / NSD2, first PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047430",
"name": "Nuclear receptor-binding SET domain-containing protein 1, fourth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047467",
"name": "E3 ubiquitin-protein ligase UHRF2, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047970",
"name": "Lysine-specific demethylase 5A, second PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047972",
"name": "Lysine-specific demethylase 5A, third PHD-finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047973",
"name": "Lysine-specific demethylase 5A, first PHD-finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047978",
"name": "Lysine-specific demethylase 5B, first PHD-finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047979",
"name": "Lysine-specific demethylase 5B, third PHD-finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR049781",
"name": "AF-10/AF-17, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR058054",
"name": "PHD finger protein MALE STERILITY 1-like, Zinc finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR034732",
"name": "Extended PHD (ePHD) domain",
"type": "Domain",
"children": [
{
"accession": "IPR039549",
"name": "JADE2, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041955",
"name": "ATX3/4/5, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041956",
"name": "ATX1/2, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041958",
"name": "KMT2A, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041959",
"name": "KMT2B, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041961",
"name": "KMT2D, ePHD1 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041964",
"name": "KMT2D, ePHD2 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041967",
"name": "KMT2C, ePHD1",
"type": "Domain",
"children": []
},
{
"accession": "IPR041968",
"name": "KMT2C, ePHD2",
"type": "Domain",
"children": []
},
{
"accession": "IPR041972",
"name": "Transcription factor 20, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042004",
"name": "BRPF2, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042005",
"name": "BRPF3, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042013",
"name": "PHF7/G2E3, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042061",
"name": "Peregrin, ePHD domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047482",
"name": "Lysine-specific demethylase 4A, extended PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR049775",
"name": "AF-10, extended PHD finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR039095",
"name": "Transcription factor 19, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR042015",
"name": "MTF2, PHD domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR042017",
"name": "PHF19, PHD domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR043319",
"name": "ASH1-like, PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047010",
"name": "PHD finger protein 1, PHD finger 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR047432",
"name": "Nuclear receptor-binding SET domain-containing protein 1, fifth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047442",
"name": "Nuclear SET domain-containing protein 2, fifth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047458",
"name": "Histone-lysine N-methyltransferase NSD3, fourth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047527",
"name": "Histone-lysine N-methyltransferase NSD3, fifth PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR055197",
"name": "Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger",
"type": "Domain",
"children": [
{
"accession": "IPR047429",
"name": "Nuclear receptor-binding SET domain-containing protein 1, third PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047441",
"name": "Nuclear SET domain-containing protein 2, third PHD finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR055198",
"name": "Histone-lysine N-methyltransferase NSD-like, PHD zinc finger",
"type": "Domain",
"children": [
{
"accession": "IPR047428",
"name": "Nuclear receptor-binding SET domain-containing protein 1, second PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047439",
"name": "Nuclear SET domain-containing protein 2, second PHD finger",
"type": "Domain",
"children": []
},
{
"accession": "IPR047456",
"name": "Histone-lysine N-methyltransferase NSD3, second PHD finger",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR059102",
"name": "PHF7/G2E3-like, PHD zinc finger domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Transcription factor 19, PHD finger",
"short": "TCF19_PHD"
},
"description": [
{
"text": "<p>TCF-19, also termed transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells [[cite:PUB00088919]]. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand [[cite:PUB00088921]].</p>\n\n<p>TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3 [[cite:PUB00048339]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00048339": {
"PMID": 19430464,
"ISBN": null,
"volume": "459",
"issue": "7248",
"year": 2009,
"title": "Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.",
"URL": null,
"raw_pages": "847-51",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Wang GG",
"Song J",
"Wang Z",
"Dormann HL",
"Casadio F",
"Li H",
"Luo JL",
"Patel DJ",
"Allis CD."
],
"DOI_URL": "http://dx.doi.org/10.1038/nature08036"
},
"PUB00088921": {
"PMID": 23860123,
"ISBN": null,
"volume": "305",
"issue": "5",
"year": 2013,
"title": "Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line.",
"URL": null,
"raw_pages": "E600-10",
"medline_journal": "Am J Physiol Endocrinol Metab",
"ISO_journal": "Am. J. Physiol. Endocrinol. Metab.",
"authors": [
"Krautkramer KA",
"Linnemann AK",
"Fontaine DA",
"Whillock AL",
"Harris TW",
"Schleis GJ",
"Truchan NA",
"Marty-Santos L",
"Lavine JA",
"Cleaver O",
"Kimple ME",
"Davis DB."
],
"DOI_URL": "https://doi.org/10.1152/ajpendo.00147.2013"
},
"PUB00088919": {
"PMID": 1868030,
"ISBN": null,
"volume": "2",
"issue": "4",
"year": 1991,
"title": "A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor.",
"URL": null,
"raw_pages": "179-86",
"medline_journal": "Cell Growth Differ",
"ISO_journal": "Cell Growth Differ.",
"authors": [
"Ku DH",
"Chang CD",
"Koniecki J",
"Cannizzaro LA",
"Boghosian-Sell L",
"Alder H",
"Baserga R."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR011011",
"name": "Zinc finger, FYVE/PHD-type",
"type": "homologous_superfamily"
},
{
"accession": "IPR013083",
"name": "Zinc finger, RING/FYVE/PHD-type",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 282,
"pathways": 0,
"proteins": 282,
"proteomes": 213,
"sets": 0,
"structural_models": {
"alphafold": 249,
"bfvd": 0
},
"structures": 0,
"taxa": 835
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
