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CHEBI:9652 - tranylcypromine
| ChEBI ID | CHEBI:9652 |
| ChEBI Name | tranylcypromine |
| Stars | |
| Definition | A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine). |
| Secondary ChEBI IDs | CHEBI:39677, CHEBI:46075 |
| Last Modified | 29 September 2025 |
| Formula | C9H11N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | EC 1.4.3.4 (monoamine oxidase) inhibitor An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4). P450 inhibitor An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances. EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor An EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of lysine-specific histone demethylase 1A (EC 1.14.99.66). |
| Applications: | anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| tranylcypromine (CHEBI:9652) has part (1R,2S)-tranylcypromine (CHEBI:131510) |
| tranylcypromine (CHEBI:9652) has part (1S,2R)-tranylcypromine (CHEBI:131511) |
| tranylcypromine (CHEBI:9652) has role antidepressant (CHEBI:35469) |
| tranylcypromine (CHEBI:9652) has role anxiolytic drug (CHEBI:35474) |
| tranylcypromine (CHEBI:9652) has role EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor (CHEBI:131509) |
| tranylcypromine (CHEBI:9652) has role EC 1.4.3.4 (monoamine oxidase) inhibitor (CHEBI:38623) |
| tranylcypromine (CHEBI:9652) has role P450 inhibitor (CHEBI:50183) |
| tranylcypromine (CHEBI:9652) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-(1R,2S)-2-phenylcyclopropan-1-amine |
| INNs | Source |
|---|---|
| tranilcipromina | DrugBank |
| tranylcypromine | KEGG DRUG |
| tranylcypromine | DrugBank |
| tranylcyprominum | DrugBank |
| Synonyms | Source |
|---|---|
| (1R*,2S*)-2-phenylcyclopropan-1-amine | ChEBI |
| (±)-trans-2-phenylcyclopropylamine | ChEBI |
| trans-2-phenylcyclopropylamine | ChEBI |
| Racemic Tranylcypromine | ChemIDplus |
| SKF 385 | ChemIDplus |
| SKF Trans-385 | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| C07155 | KEGG COMPOUND |
| CPD-17677 | MetaCyc |
| D08625 | KEGG DRUG |
| DB00752 | DrugBank |
| HMDB0014890 | HMDB |
| TPA | PDBeChem |
| Tranylcypromine | Wikipedia |
| Citations |
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