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CHEBI:9652 - tranylcypromine
| ChEBI ID | CHEBI:9652 |
| ChEBI Name | tranylcypromine |
| Stars | |
| Definition | A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine). |
| Secondary ChEBI IDs | CHEBI:39677, CHEBI:46075 |
| Last Modified | 29 September 2025 |
| Formula | C9H11N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | EC 1.4.3.4 (monoamine oxidase) inhibitor An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4). EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor An EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of lysine-specific histone demethylase 1A (EC 1.14.99.66). P450 inhibitor An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances. |
| Applications: | anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| tranylcypromine (CHEBI:9652) has part (1R,2S)-tranylcypromine (CHEBI:131510) |
| tranylcypromine (CHEBI:9652) has part (1S,2R)-tranylcypromine (CHEBI:131511) |
| tranylcypromine (CHEBI:9652) has role antidepressant (CHEBI:35469) |
| tranylcypromine (CHEBI:9652) has role anxiolytic drug (CHEBI:35474) |
| tranylcypromine (CHEBI:9652) has role EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor (CHEBI:131509) |
| tranylcypromine (CHEBI:9652) has role EC 1.4.3.4 (monoamine oxidase) inhibitor (CHEBI:38623) |
| tranylcypromine (CHEBI:9652) has role P450 inhibitor (CHEBI:50183) |
| tranylcypromine (CHEBI:9652) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-(1R,2S)-2-phenylcyclopropan-1-amine |
| INNs | Source |
|---|---|
| tranylcyprominum | DrugBank |
| tranylcypromine | DrugBank |
| tranilcipromina | DrugBank |
| tranylcypromine | KEGG DRUG |
| Synonyms | Source |
|---|---|
| Tranylcypromine | KEGG COMPOUND |
| Transamine | DrugBank |
| Tranylcypromin | DrugBank |
| (±)-trans-2-phenylcyclopropylamine | ChEBI |
| trans-DL-2-Phenylcyclopropylamine | ChemIDplus |
| Racemic Tranylcypromine | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| C07155 | KEGG COMPOUND |
| TPA | PDBeChem |
| D08625 | KEGG DRUG |
| DB00752 | DrugBank |
| HMDB0014890 | HMDB |
| CPD-17677 | MetaCyc |
| Tranylcypromine | Wikipedia |
| Citations |
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