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CHEBI:9637 - torasemide

Default Structure
ChEBI IDCHEBI:9637
ChEBI Nametorasemide
Stars
DefinitionAn N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure.
Last Modified25 June 2020
DownloadsMolfile
FormulaC16H20N4O3S
Net Charge0
Average Mass348.428
Monoisotopic Mass348.12561
SMILESCc1cccc(Nc2ccncc2S(=O)(=O)NC(=O)NC(C)C)c1
InChIInChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
InChIKeyNGBFQHCMQULJNZ-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Applications:
loop diuretic  A diuretic that acts on the ascending loop of Henle in the kidney.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
torasemide (CHEBI:9637) has functional parent 4-aminopyridine (CHEBI:34385)
torasemide (CHEBI:9637) has role antihypertensive agent (CHEBI:35674)
torasemide (CHEBI:9637) has role loop diuretic (CHEBI:77608)
torasemide (CHEBI:9637) is a N-sulfonylurea (CHEBI:76983)
torasemide (CHEBI:9637) is a aminopyridine (CHEBI:38207)
torasemide (CHEBI:9637) is a secondary amino compound (CHEBI:50995)
Incoming Relation(s)
4'-hydroxy torasemide (CHEBI:155915) has functional parent torasemide (CHEBI:9637)
hydroxy torasemide (CHEBI:155897) has functional parent torasemide (CHEBI:9637)
torasemide carboxylic acid (CHEBI:155916) has functional parent torasemide (CHEBI:9637)
IUPAC Name 
4-(3-methylanilino)-N-(propan-2-ylcarbamoyl)pyridine-3-sulfonamide
INNs  Source
torasemidaWHO MedNet
torasemideWHO MedNet
torasémideWHO MedNet
torasemidumWHO MedNet
Synonyms  Source
1-isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)ureaChemIDplus
AC 4464ChemIDplus
AC-4464DrugBank
AC4464ChemIDplus
BM 02015ChemIDplus
BM-02.015DrugBank
Brand Names  Source
DemadexKEGG DRUG
LupracKEGG DRUG
ToremChEBI
UnatChEBI
Manual XrefsDatabases
2708DrugCentral
D00382KEGG DRUG
DB00214DrugBank
HMDB0014359HMDB
LSM-2662LINCS
TorasemideWikipedia
Registry NumbersSources
Reaxys:498515Reaxys
CAS:56211-40-6ChemIDplus
CAS:56211-40-6KEGG DRUG
Citations