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CHEBI:9352 - sulindac
| Formula | C20H17FO3S |
| Net Charge | 0 |
| Average Mass | 356.418 |
| Monoisotopic Mass | 356.08824 |
| SMILES | CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)=O)cc1 |
| InChI | InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- |
| InChIKey | MLKXDPUZXIRXEP-MFOYZWKCSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| Biological Roles: | non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. tocolytic agent Any compound used to suppress premature labour and immature birth by suppressing uterine contractions. antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| sulindac (CHEBI:9352) has functional parent acetic acid (CHEBI:15366) |
| sulindac (CHEBI:9352) has role analgesic (CHEBI:35480) |
| sulindac (CHEBI:9352) has role antineoplastic agent (CHEBI:35610) |
| sulindac (CHEBI:9352) has role antipyretic (CHEBI:35493) |
| sulindac (CHEBI:9352) has role apoptosis inducer (CHEBI:68495) |
| sulindac (CHEBI:9352) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544) |
| sulindac (CHEBI:9352) has role non-narcotic analgesic (CHEBI:35481) |
| sulindac (CHEBI:9352) has role non-steroidal anti-inflammatory drug (CHEBI:35475) |
| sulindac (CHEBI:9352) has role prodrug (CHEBI:50266) |
| sulindac (CHEBI:9352) has role tocolytic agent (CHEBI:66993) |
| sulindac (CHEBI:9352) is a monocarboxylic acid (CHEBI:25384) |
| sulindac (CHEBI:9352) is a organofluorine compound (CHEBI:37143) |
| sulindac (CHEBI:9352) is a sulfoxide (CHEBI:22063) |
| Incoming Relation(s) |
| nitrosulindac (CHEBI:75321) has functional parent sulindac (CHEBI:9352) |
| sulindac sulfide (CHEBI:75408) has functional parent sulindac (CHEBI:9352) |
| sulindac sulfone (CHEBI:64212) has functional parent sulindac (CHEBI:9352) |
| IUPAC Name |
|---|
| {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid |
| INNs | Source |
|---|---|
| sulindac | ChemIDplus |
| sulindac | WHO MedNet |
| sulindaco | ChemIDplus |
| Sulindacum | ChemIDplus |
| Synonyms | Source |
|---|---|
| cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid | ChemIDplus |
| cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid | ChemIDplus |
| Sulindac | KEGG COMPOUND |
| (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid | ChemIDplus |
| Brand Name | Source |
|---|---|
| Clinoril | DrugBank |
| Registry Numbers | Sources |
|---|---|
| Reaxys:2951842 | Reaxys |
| CAS:38194-50-2 | NIST Chemistry WebBook |
| CAS:38194-50-2 | ChemIDplus |
| CAS:38194-50-2 | KEGG COMPOUND |
| Citations |
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