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CHEBI:9352 - sulindac
| Formula | C20H17FO3S |
| Net Charge | 0 |
| Average Mass | 356.418 |
| Monoisotopic Mass | 356.08824 |
| SMILES | CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)=O)cc1 |
| InChI | InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- |
| InChIKey | MLKXDPUZXIRXEP-MFOYZWKCSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| Biological Roles: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. |
| Applications: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. tocolytic agent Any compound used to suppress premature labour and immature birth by suppressing uterine contractions. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| sulindac (CHEBI:9352) has functional parent acetic acid (CHEBI:15366) |
| sulindac (CHEBI:9352) has role analgesic (CHEBI:35480) |
| sulindac (CHEBI:9352) has role antineoplastic agent (CHEBI:35610) |
| sulindac (CHEBI:9352) has role antipyretic (CHEBI:35493) |
| sulindac (CHEBI:9352) has role apoptosis inducer (CHEBI:68495) |
| sulindac (CHEBI:9352) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544) |
| sulindac (CHEBI:9352) has role non-narcotic analgesic (CHEBI:35481) |
| sulindac (CHEBI:9352) has role non-steroidal anti-inflammatory drug (CHEBI:35475) |
| sulindac (CHEBI:9352) has role prodrug (CHEBI:50266) |
| sulindac (CHEBI:9352) has role tocolytic agent (CHEBI:66993) |
| sulindac (CHEBI:9352) is a monocarboxylic acid (CHEBI:25384) |
| sulindac (CHEBI:9352) is a organofluorine compound (CHEBI:37143) |
| sulindac (CHEBI:9352) is a sulfoxide (CHEBI:22063) |
| Incoming Relation(s) |
| nitrosulindac (CHEBI:75321) has functional parent sulindac (CHEBI:9352) |
| sulindac sulfide (CHEBI:75408) has functional parent sulindac (CHEBI:9352) |
| sulindac sulfone (CHEBI:64212) has functional parent sulindac (CHEBI:9352) |
| IUPAC Name |
|---|
| {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid |
| INNs | Source |
|---|---|
| sulindac | ChemIDplus |
| sulindac | WHO MedNet |
| sulindaco | ChemIDplus |
| Sulindacum | ChemIDplus |
| Synonyms | Source |
|---|---|
| cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid | ChemIDplus |
| cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid | ChemIDplus |
| Sulindac | KEGG COMPOUND |
| (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid | ChemIDplus |
| Brand Name | Source |
|---|---|
| Clinoril | DrugBank |
| Registry Numbers | Sources |
|---|---|
| Reaxys:2951842 | Reaxys |
| CAS:38194-50-2 | NIST Chemistry WebBook |
| CAS:38194-50-2 | ChemIDplus |
| CAS:38194-50-2 | KEGG COMPOUND |
| Citations |
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