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CHEBI:90950 - Orkambi
| ChEBI ID | CHEBI:90950 |
| ChEBI Name | Orkambi |
| Stars | |
| Definition | A two-drug mixture consisting of lumacaftor and ivacaftor, which is used for the treatment of cystic fibrosis. |
| Last Modified | 14 January 2016 |
| Submitter | Steve |
| Roles Classification |
|---|
| Biological Role: | CFTR potentiator A membrane transport modulator that restores the chloride ion transport ability of defective cystic fibrosis transmembrane conductance regulator (CFTR) genes. |
| Application: | orphan drug Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| Orkambi (CHEBI:90950) has part ivacaftor (CHEBI:66901) |
| Orkambi (CHEBI:90950) has part lumacaftor (CHEBI:90951) |
| Orkambi (CHEBI:90950) has role CFTR potentiator (CHEBI:66902) |
| Orkambi (CHEBI:90950) has role orphan drug (CHEBI:71031) |
| Orkambi (CHEBI:90950) is a mixture (CHEBI:60004) |
| Synonyms | Source |
|---|---|
| Lumacaftor - ivacaftor mixt | KEGG DRUG |
| Ivacaftor - lumacaftor | ChemIDplus |
| Ivacaftor and lumacaftor | ChemIDplus |
| Ivacaftor / lumacaftor | ChemIDplus |
| Ivacaftor mixture with lumacaftor | ChemIDplus |
| Brand Name | Source |
|---|---|
| Orkambi | KEGG DRUG |
| Manual Xrefs | Databases |
|---|---|
| D10685 | KEGG DRUG |
| Citations |
|---|