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CHEBI:90623 - vatalanib succinate

ChEBI IDCHEBI:90623
ChEBI Namevatalanib succinate
Stars
DefinitionA succinate salt obtained by combining vatalanib with one molar equivalent of succinic acid. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit.
Last Modified3 December 2015
SubmitterSteve
DownloadsMolfile
FormulaC20H15ClN4.C4H6O4
Net Charge0
Average Mass464.909
Monoisotopic Mass464.12513
SMILESClc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1.O=C(O)CCC(=O)O
InChIInChI=1S/C20H15ClN4.C4H6O4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;5-3(6)1-2-4(7)8/h1-12H,13H2,(H,23,25);1-2H2,(H,5,6)(H,7,8)
InChIKeyLLDWLPRYLVPDTG-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
vascular endothelial growth factor receptor antagonist  An antagonist at the vascular endothelial growth factor receptor.
Applications:
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
vatalanib succinate (CHEBI:90623) has part vatalanib (CHEBI:90620)
vatalanib succinate (CHEBI:90623) has role angiogenesis inhibitor (CHEBI:48422)
vatalanib succinate (CHEBI:90623) has role antineoplastic agent (CHEBI:35610)
vatalanib succinate (CHEBI:90623) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
vatalanib succinate (CHEBI:90623) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
vatalanib succinate (CHEBI:90623) is a succinate salt (CHEBI:51381)
Synonyms  Source
vatalanib monosuccinateChEBI
PTK 787ChemIDplus
PTK 787/ZK 222584ChemIDplus
ZK 222584ChemIDplus
PTK-787ChemIDplus
CGP 79787DChemIDplus
Manual XrefsDatabases
VatalanibWikipedia
Registry NumbersSources
Reaxys:8664962Reaxys
CAS:212142-18-2ChemIDplus
Citations