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CHEBI:90623 - vatalanib succinate

Default Structure
ChEBI IDCHEBI:90623
ChEBI Namevatalanib succinate
Stars
DefinitionA succinate salt obtained by combining vatalanib with one molar equivalent of succinic acid. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit.
Last Modified3 December 2015
SubmitterSteve
DownloadsMolfile
FormulaC20H15ClN4.C4H6O4
Net Charge0
Average Mass464.909
Monoisotopic Mass464.12513
SMILESClc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1.O=C(O)CCC(=O)O
InChIInChI=1S/C20H15ClN4.C4H6O4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;5-3(6)1-2-4(7)8/h1-12H,13H2,(H,23,25);1-2H2,(H,5,6)(H,7,8)
InChIKeyLLDWLPRYLVPDTG-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
vascular endothelial growth factor receptor antagonist  An antagonist at the vascular endothelial growth factor receptor.
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
ChEBI Ontology
Outgoing Relation(s)
vatalanib succinate (CHEBI:90623) has part vatalanib (CHEBI:90620)
vatalanib succinate (CHEBI:90623) has role angiogenesis inhibitor (CHEBI:48422)
vatalanib succinate (CHEBI:90623) has role antineoplastic agent (CHEBI:35610)
vatalanib succinate (CHEBI:90623) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
vatalanib succinate (CHEBI:90623) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
vatalanib succinate (CHEBI:90623) is a succinate salt (CHEBI:51381)
Synonyms  Source
CGP 79787DChemIDplus
PTK 787ChemIDplus
PTK-787ChemIDplus
PTK 787/ZK 222584ChemIDplus
PTK787/ZK222584ChemIDplus
vatalanib monosuccinateChEBI
Manual XrefsDatabases
VatalanibWikipedia
Registry NumbersSources
Reaxys:8664962Reaxys
CAS:212142-18-2ChemIDplus
Citations