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CHEBI:90196 - rac-selisistat
| ChEBI ID | CHEBI:90196 |
| ChEBI Name | rac-selisistat |
| Stars | |
| ASCII Name | rac-selisistat |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-selisistat. It is a potent sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) and is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. The active isomer (EX-243) gives similar results and potency; the enantiomer (EX-242) is inactive. |
| Last Modified | 13 November 2015 |
| Submitter | Margaret Duesbury |
| Formula | C13H13ClN2O |
| Net Charge | 0 |
| Average Mass | 248.709 |
| Monoisotopic Mass | 248.07164 |
| Roles Classification |
|---|
| Biological Role: | Sir1 inhibitor An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir1. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| rac-selisistat (CHEBI:90196) has part (R)-selisistat (CHEBI:90370) |
| rac-selisistat (CHEBI:90196) has part (S)-selisistat (CHEBI:90371) |
| rac-selisistat (CHEBI:90196) has role Sir1 inhibitor (CHEBI:90375) |
| rac-selisistat (CHEBI:90196) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| INNs | Source |
|---|---|
| selisistat | WHO MedNet |
| sálisistat | WHO MedNet |
| selisistatum | WHO MedNet |
| selisistat | WHO MedNet |
| Synonyms | Source |
|---|---|
| EX-527 | ChEBI |
| rac-EX-527 | ChEBI |
| Registry Numbers | Sources |
|---|---|
| Reaxys:416178 | Reaxys |
| CAS:49843-98-3 | ChemIDplus |
| Citations |
|---|