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CHEBI:87681 - ranolazine
| ChEBI ID | CHEBI:87681 |
| ChEBI Name | ranolazine |
| Stars | |
| Definition | A racemate comprising equal amounts of (R)- and (S)-ranolazine. Used for treatment of chronic angina. |
| Last Modified | 22 February 2017 |
| Submitter | Steve |
| Formula | C24H33N3O4 |
| Net Charge | 0 |
| Average Mass | 427.537 |
| Monoisotopic Mass | 427.24711 |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | sodium channel blocker An agent that inhibits sodium influx through cell membranes. |
| Applications: | hypoglycemic agent A drug which lowers the blood glucose level. renoprotective agent Any compound that is able to prevent damage to the kidneys. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. antispasmodic drug A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| ranolazine (CHEBI:87681) has part (R)-ranolazine (CHEBI:87696) |
| ranolazine (CHEBI:87681) has part (S)-ranolazine (CHEBI:87693) |
| ranolazine (CHEBI:87681) has role anti-arrhythmia drug (CHEBI:38070) |
| ranolazine (CHEBI:87681) has role antihypertensive agent (CHEBI:35674) |
| ranolazine (CHEBI:87681) has role antispasmodic drug (CHEBI:53784) |
| ranolazine (CHEBI:87681) has role cardiovascular drug (CHEBI:35554) |
| ranolazine (CHEBI:87681) has role hypoglycemic agent (CHEBI:35526) |
| ranolazine (CHEBI:87681) has role renoprotective agent (CHEBI:231911) |
| ranolazine (CHEBI:87681) has role sodium channel blocker (CHEBI:38633) |
| ranolazine (CHEBI:87681) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide |
| INNs | Source |
|---|---|
| ranolazina | WHO MedNet |
| ranolazine | KEGG DRUG |
| Synonyms | Source |
|---|---|
| Aspruzyo | ChEMBL |
| CVT-303 | ChEMBL |
| rac-ranolazine | ChEBI |
| (RS)-ranolazine | ChEBI |
| (+-)-N-(2,6-Dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide | ChemIDplus |
| NSC-759100 | ChEMBL |
| Brand Names | Source |
|---|---|
| Aspruzyo sprinkle | ChEMBL |
| Ranexa | ChemIDplus |
| Ranexa (previously latixa) | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| D05700 | KEGG DRUG |
| DB00243 | DrugBank |
| EP126449 | Patent |
| Ranolazine | Wikipedia |
| US4567264 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:8234797 | Reaxys |
| CAS:95635-55-5 | KEGG DRUG |
| CAS:95635-55-5 | ChemIDplus |
| Citations |
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