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CHEBI:8462 - promethazine hydrochloride
| Formula | C17H20N2S.HCl |
| Net Charge | 0 |
| Average Mass | 320.889 |
| Monoisotopic Mass | 320.11140 |
| SMILES | CC(CN1c2ccccc2Sc2ccccc21)N(C)C.Cl |
| InChI | InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Roles: | anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | antipruritic drug A drug, usually applied topically, that relieves pruritus (itching). H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. anti-allergic agent A drug used to treat allergic reactions. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. local anaesthetic Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| promethazine hydrochloride (CHEBI:8462) has part promethazine(1+) (CHEBI:61214) |
| promethazine hydrochloride (CHEBI:8462) has role analgesic (CHEBI:35480) |
| promethazine hydrochloride (CHEBI:8462) has role anti-allergic agent (CHEBI:50857) |
| promethazine hydrochloride (CHEBI:8462) has role anticoronaviral agent (CHEBI:149553) |
| promethazine hydrochloride (CHEBI:8462) has role antiemetic (CHEBI:50919) |
| promethazine hydrochloride (CHEBI:8462) has role antipruritic drug (CHEBI:59683) |
| promethazine hydrochloride (CHEBI:8462) has role dermatologic drug (CHEBI:50177) |
| promethazine hydrochloride (CHEBI:8462) has role geroprotector (CHEBI:176497) |
| promethazine hydrochloride (CHEBI:8462) has role H1-receptor antagonist (CHEBI:37955) |
| promethazine hydrochloride (CHEBI:8462) has role local anaesthetic (CHEBI:36333) |
| promethazine hydrochloride (CHEBI:8462) has role ophthalmology drug (CHEBI:66981) |
| promethazine hydrochloride (CHEBI:8462) has role sedative (CHEBI:35717) |
| promethazine hydrochloride (CHEBI:8462) is a hydrochloride (CHEBI:36807) |
| IUPAC Name |
|---|
| N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride |
| Synonyms | Source |
|---|---|
| 10-(2-Dimethylamino-1-propyl)phenothiazine hydrochloride | ChemIDplus |
| (+-)-10-(2-(Dimethylamino)propyl)phenothiazine monohydrochloride | ChemIDplus |
| 10-(3-Dimethylaminoisopropyl)phenothiazine hydrochloride | ChemIDplus |
| N-(2'-dimethylamino-2'-methyl)ethylphenothiazine hydrochloride | ChemIDplus |
| N-(2-dimethylaminopropyl-1)phenothiazine hydrochloride | ChemIDplus |
| promethazine HCl | ChemIDplus |
| Brand Names | Source |
|---|---|
| Anergan 25 | ChEMBL |
| Fenergan | DrugBank |
| Genphen | ChEMBL |
| Mepergan | ChEMBL |
| Mymethazine fortis | ChEMBL |
| Phenergan | DrugBank |
| Manual Xrefs | Databases |
|---|---|
| D00480 | KEGG DRUG |
| DBSALT000427 | DrugBank |
| Registry Numbers | Sources |
|---|---|
| Reaxys:4166397 | Reaxys |
| CAS:58-33-3 | ChemIDplus |
| Citations |
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