EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:84116 - triprolidine

ChEBI IDCHEBI:84116
ChEBI Nametriprolidine
Stars
DefinitionAn N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.
Last Modified22 February 2017
SubmitterGareth Owen
DownloadsMolfile
FormulaC19H22N2
Net Charge0
Average Mass278.399
Monoisotopic Mass278.17830
SMILES[H]/C(CN1CCCC1)=C(/c1ccc(C)cc1)c1ccccn1
InChIInChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
InChIKeyCBEQULMOCCWAQT-WOJGMQOQSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Application:
H1-receptor antagonist  H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
ChEBI Ontology
Outgoing Relation(s)
triprolidine (CHEBI:84116) has role H1-receptor antagonist (CHEBI:37955)
triprolidine (CHEBI:84116) is a N-alkylpyrrolidine (CHEBI:46775)
triprolidine (CHEBI:84116) is a olefinic compound (CHEBI:78840)
triprolidine (CHEBI:84116) is a pyridines (CHEBI:26421)
triprolidine (CHEBI:84116) is conjugate base of triprolidine(1+) (CHEBI:84117)
Incoming Relation(s)
triprolidine(1+) (CHEBI:84117) is conjugate acid of triprolidine (CHEBI:84116)
IUPAC Name 
2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine
INNs  Source
triprolidineWHO MedNet
triprolidineChemIDplus
tripolidinaChemIDplus
triprolidinumChemIDplus
Synonyms  Source
trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-eneChemIDplus
trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridineChemIDplus
trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-eneChemIDplus
(E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridineNIST Chemistry WebBook
Manual XrefsDatabases
US2712020Patent
US2712023Patent
TriprolidineWikipedia
D08648KEGG DRUG
DB00427DrugBank
HMDB0014571HMDB
2763DrugCentral
Registry NumbersSources
Reaxys:87215Reaxys
CAS:486-12-4ChemIDplus
CAS:486-12-4NIST Chemistry WebBook
Citations