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CHEBI:83928 - tubulozole
| ChEBI ID | CHEBI:83928 |
| ChEBI Name | tubulozole |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (2R,4R)- and (2S,4S)-tubulozole. A synthetic anticancer drug that interferes with the structure and function of microtubules in both interphase and mitotic cells. |
| Last Modified | 28 November 2014 |
| Submitter | Steve |
| Roles Classification |
|---|
| Biological Role: | microtubule-destabilising agent Any substance that interacts with tubulin to inhibit polymerisation of microtubules. |
| Application: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| tubulozole (CHEBI:83928) has part (R,R)-tubulozole (CHEBI:83932) |
| tubulozole (CHEBI:83928) has part (S,S)-tubulozole (CHEBI:83933) |
| tubulozole (CHEBI:83928) has role antineoplastic agent (CHEBI:35610) |
| tubulozole (CHEBI:83928) has role microtubule-destabilising agent (CHEBI:61951) |
| tubulozole (CHEBI:83928) is a racemate (CHEBI:60911) |
| IUPAC Names |
|---|
| rac-ethyl [4-({[(2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)phenyl]carbamate |
| rac-ethyl [4-({[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)phenyl]carbamate |
| INNs | Source |
|---|---|
| tubulozol | ChemIDplus |
| tubulozole | ChemIDplus |
| tubulozolum | ChemIDplus |
| tubulazole | ChemIDplus |
| Synonyms | Source |
|---|---|
| Ethyl (+-)-cis-p-(((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-p-ylmethylthio)thio))carbanilate | ChemIDplus |
| Tubulozole C | ChemIDplus |
| R 46846 | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:8803875 | Reaxys |
| CAS:84697-22-3 | ChemIDplus |
| Citations |
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