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CHEBI:77543 - ebselen
| Formula | C13H9NOSe |
| Net Charge | 0 |
| Average Mass | 274.181 |
| Monoisotopic Mass | 274.98494 |
| SMILES | O=c1c2ccccc2[se]n1-c1ccccc1 |
| InChI | InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H |
| InChIKey | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Roles: | antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. |
| Biological Roles: | anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1). EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69). EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34). EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor An EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor that interferes with the action of UDP-glucose 4-epimerase (EC 5.1.3.2). EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12). genotoxin A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells. EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of inositol-phosphate phosphatase (EC 3.1.3.25). antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. antiviral agent A substance that destroys or inhibits replication of viruses. EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7). EC 3.5.4.1 (cytosine deaminase) inhibitor An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of cytosine deaminase (EC 3.5.4.1). EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33). ferroptosis inhibitor Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of acyl-CoA dehydrogenase (NADP+), EC 1.3.1.8. |
| Applications: | antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. enzyme mimic Any small molecule that mimics the action of an enzyme. anti-inflammatory drug A substance that reduces or suppresses inflammation. hypoglycemic agent A drug which lowers the blood glucose level. hepatoprotective agent Any compound that is able to prevent damage to the liver. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| ebselen (CHEBI:77543) has role anti-inflammatory drug (CHEBI:35472) |
| ebselen (CHEBI:77543) has role antibacterial agent (CHEBI:33282) |
| ebselen (CHEBI:77543) has role anticoronaviral agent (CHEBI:149553) |
| ebselen (CHEBI:77543) has role antidepressant (CHEBI:35469) |
| ebselen (CHEBI:77543) has role antifungal agent (CHEBI:35718) |
| ebselen (CHEBI:77543) has role antineoplastic agent (CHEBI:35610) |
| ebselen (CHEBI:77543) has role antioxidant (CHEBI:22586) |
| ebselen (CHEBI:77543) has role antipsychotic agent (CHEBI:35476) |
| ebselen (CHEBI:77543) has role antiviral agent (CHEBI:22587) |
| ebselen (CHEBI:77543) has role apoptosis inducer (CHEBI:68495) |
| ebselen (CHEBI:77543) has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor (CHEBI:64996) |
| ebselen (CHEBI:77543) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964) |
| ebselen (CHEBI:77543) has role EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP+)] inhibitor (CHEBI:78377) |
| ebselen (CHEBI:77543) has role EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor (CHEBI:77402) |
| ebselen (CHEBI:77543) has role EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor (CHEBI:78379) |
| ebselen (CHEBI:77543) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434) |
| ebselen (CHEBI:77543) has role EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor (CHEBI:173094) |
| ebselen (CHEBI:77543) has role EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor (CHEBI:147285) |
| ebselen (CHEBI:77543) has role EC 3.5.4.1 (cytosine deaminase) inhibitor (CHEBI:78380) |
| ebselen (CHEBI:77543) has role EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor (CHEBI:78384) |
| ebselen (CHEBI:77543) has role enzyme mimic (CHEBI:78152) |
| ebselen (CHEBI:77543) has role ferroptosis inhibitor (CHEBI:173084) |
| ebselen (CHEBI:77543) has role genotoxin (CHEBI:50902) |
| ebselen (CHEBI:77543) has role hepatoprotective agent (CHEBI:62868) |
| ebselen (CHEBI:77543) has role hypoglycemic agent (CHEBI:35526) |
| ebselen (CHEBI:77543) has role neuroprotective agent (CHEBI:63726) |
| ebselen (CHEBI:77543) has role radical scavenger (CHEBI:48578) |
| ebselen (CHEBI:77543) is a benzoselenazole (CHEBI:78151) |
| IUPAC Name |
|---|
| 2-phenyl-1,2-benzoselenazol-3(2H)-one |
| INNs | Source |
|---|---|
| ebselen | WHO MedNet |
| ebsélène | WHO MedNet |
| ebseleno | WHO MedNet |
| ebselenum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 2-phenyl-1,2-benzoselenazol-3-one | SUBMITTER |
| DR-3305 | LINCS |
| DR3305 | LINCS |
| NSC-639762 | ChEMBL |
| NSC-757883 | ChEMBL |
| PZ 51 | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:164926 | Reaxys |
| CAS:60940-34-3 | ChemIDplus |
| Citations |
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