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CHEBI:77543 - ebselen
| Formula | C13H9NOSe |
| Net Charge | 0 |
| Average Mass | 274.181 |
| Monoisotopic Mass | 274.98494 |
| SMILES | O=c1c2ccccc2[se]n1-c1ccccc1 |
| InChI | InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H |
| InChIKey | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Roles: | radical scavenger A role played by a substance that can react readily with, and thereby eliminate, radicals. antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| Biological Roles: | EC 3.5.4.1 (cytosine deaminase) inhibitor An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of cytosine deaminase (EC 3.5.4.1). EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7). antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69). ferroptosis inhibitor Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1). EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33). EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34). EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12). genotoxin A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells. antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of inositol-phosphate phosphatase (EC 3.1.3.25). anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor An EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor that interferes with the action of UDP-glucose 4-epimerase (EC 5.1.3.2). EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of acyl-CoA dehydrogenase (NADP+), EC 1.3.1.8. |
| Applications: | enzyme mimic Any small molecule that mimics the action of an enzyme. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. anti-inflammatory drug A substance that reduces or suppresses inflammation. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. hepatoprotective agent Any compound that is able to prevent damage to the liver. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| ebselen (CHEBI:77543) has role anti-inflammatory drug (CHEBI:35472) |
| ebselen (CHEBI:77543) has role antibacterial agent (CHEBI:33282) |
| ebselen (CHEBI:77543) has role anticoronaviral agent (CHEBI:149553) |
| ebselen (CHEBI:77543) has role antifungal agent (CHEBI:35718) |
| ebselen (CHEBI:77543) has role antineoplastic agent (CHEBI:35610) |
| ebselen (CHEBI:77543) has role antioxidant (CHEBI:22586) |
| ebselen (CHEBI:77543) has role apoptosis inducer (CHEBI:68495) |
| ebselen (CHEBI:77543) has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor (CHEBI:64996) |
| ebselen (CHEBI:77543) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964) |
| ebselen (CHEBI:77543) has role EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP+)] inhibitor (CHEBI:78377) |
| ebselen (CHEBI:77543) has role EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor (CHEBI:77402) |
| ebselen (CHEBI:77543) has role EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor (CHEBI:78379) |
| ebselen (CHEBI:77543) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434) |
| ebselen (CHEBI:77543) has role EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor (CHEBI:173094) |
| ebselen (CHEBI:77543) has role EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor (CHEBI:147285) |
| ebselen (CHEBI:77543) has role EC 3.5.4.1 (cytosine deaminase) inhibitor (CHEBI:78380) |
| ebselen (CHEBI:77543) has role EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor (CHEBI:78384) |
| ebselen (CHEBI:77543) has role enzyme mimic (CHEBI:78152) |
| ebselen (CHEBI:77543) has role ferroptosis inhibitor (CHEBI:173084) |
| ebselen (CHEBI:77543) has role genotoxin (CHEBI:50902) |
| ebselen (CHEBI:77543) has role hepatoprotective agent (CHEBI:62868) |
| ebselen (CHEBI:77543) has role neuroprotective agent (CHEBI:63726) |
| ebselen (CHEBI:77543) has role radical scavenger (CHEBI:48578) |
| ebselen (CHEBI:77543) is a benzoselenazole (CHEBI:78151) |
| IUPAC Name |
|---|
| 2-phenyl-1,2-benzoselenazol-3(2H)-one |
| INNs | Source |
|---|---|
| ebselen | WHO MedNet |
| ebsélène | WHO MedNet |
| ebseleno | WHO MedNet |
| ebselenum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 2-phenyl-1,2-benzoselenazol-3-one | SUBMITTER |
| DR-3305 | LINCS |
| DR3305 | LINCS |
| PZ 51 | ChemIDplus |
| SPI-1005 | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:164926 | Reaxys |
| CAS:60940-34-3 | ChemIDplus |
| Citations |
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