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CHEBI:77543 - ebselen

Default Structure
ChEBI IDCHEBI:77543
ChEBI Nameebselen
Stars
DefinitionA benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Last Modified26 May 2021
SubmitterMaria Costanzo
DownloadsMolfile
FormulaC13H9NOSe
Net Charge0
Average Mass274.181
Monoisotopic Mass274.98494
SMILESO=c1c2ccccc2[se]n1-c1ccccc1
InChIInChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChIKeyDYEFUKCXAQOFHX-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Roles:
antioxidant  A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
radical scavenger  A role played by a substance that can react readily with, and thereby eliminate, radicals.
Biological Roles:
genotoxin  A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
antiviral agent  A substance that destroys or inhibits replication of viruses.
EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor  An EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor that interferes with the action of UDP-glucose 4-epimerase (EC 5.1.3.2).
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor  An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of acyl-CoA dehydrogenase (NADP+), EC 1.3.1.8.
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor  An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7).
EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor  An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of inositol-phosphate phosphatase (EC 3.1.3.25).
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor  An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12).
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor  A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
antibacterial agent  A substance (or active part thereof) that kills or slows the growth of bacteria.
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor  An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69).
ferroptosis inhibitor  Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
anticoronaviral agent  Any antiviral agent which inhibits the activity of coronaviruses.
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor  A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33).
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
EC 3.5.4.1 (cytosine deaminase) inhibitor  An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of cytosine deaminase (EC 3.5.4.1).
Applications:
hypoglycemic agent  A drug which lowers the blood glucose level.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
hepatoprotective agent  Any compound that is able to prevent damage to the liver.
enzyme mimic  Any small molecule that mimics the action of an enzyme.
antipsychotic agent  Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
anti-inflammatory drug  A substance that reduces or suppresses inflammation.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
ChEBI Ontology
Outgoing Relation(s)
ebselen (CHEBI:77543) has role anti-inflammatory drug (CHEBI:35472)
ebselen (CHEBI:77543) has role antibacterial agent (CHEBI:33282)
ebselen (CHEBI:77543) has role anticoronaviral agent (CHEBI:149553)
ebselen (CHEBI:77543) has role antidepressant (CHEBI:35469)
ebselen (CHEBI:77543) has role antifungal agent (CHEBI:35718)
ebselen (CHEBI:77543) has role antineoplastic agent (CHEBI:35610)
ebselen (CHEBI:77543) has role antioxidant (CHEBI:22586)
ebselen (CHEBI:77543) has role antipsychotic agent (CHEBI:35476)
ebselen (CHEBI:77543) has role antiviral agent (CHEBI:22587)
ebselen (CHEBI:77543) has role apoptosis inducer (CHEBI:68495)
ebselen (CHEBI:77543) has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor (CHEBI:64996)
ebselen (CHEBI:77543) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964)
ebselen (CHEBI:77543) has role EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP+)] inhibitor (CHEBI:78377)
ebselen (CHEBI:77543) has role EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor (CHEBI:77402)
ebselen (CHEBI:77543) has role EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor (CHEBI:78379)
ebselen (CHEBI:77543) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
ebselen (CHEBI:77543) has role EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor (CHEBI:173094)
ebselen (CHEBI:77543) has role EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor (CHEBI:147285)
ebselen (CHEBI:77543) has role EC 3.5.4.1 (cytosine deaminase) inhibitor (CHEBI:78380)
ebselen (CHEBI:77543) has role EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor (CHEBI:78384)
ebselen (CHEBI:77543) has role enzyme mimic (CHEBI:78152)
ebselen (CHEBI:77543) has role ferroptosis inhibitor (CHEBI:173084)
ebselen (CHEBI:77543) has role genotoxin (CHEBI:50902)
ebselen (CHEBI:77543) has role hepatoprotective agent (CHEBI:62868)
ebselen (CHEBI:77543) has role hypoglycemic agent (CHEBI:35526)
ebselen (CHEBI:77543) has role neuroprotective agent (CHEBI:63726)
ebselen (CHEBI:77543) has role radical scavenger (CHEBI:48578)
ebselen (CHEBI:77543) is a benzoselenazole (CHEBI:78151)
IUPAC Name 
2-phenyl-1,2-benzoselenazol-3(2H)-one
INNs  Source
ebselenWHO MedNet
ebsélèneWHO MedNet
ebselenoWHO MedNet
ebselenumWHO MedNet
Synonyms  Source
2-phenyl-1,2-benzoselenazol-3-oneSUBMITTER
DR-3305LINCS
DR3305LINCS
NSC-639762ChEMBL
NSC-757883ChEMBL
PZ 51ChemIDplus
Manual XrefsDatabases
3082ChemSpider
DB12610DrugBank
EbselenWikipedia
LSM-2644LINCS
Registry NumbersSources
Reaxys:164926Reaxys
CAS:60940-34-3ChemIDplus
Citations