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CHEBI:7731 - ofloxacin
| ChEBI ID | CHEBI:7731 |
| ChEBI Name | ofloxacin |
| Stars | |
| Definition | A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. |
| Secondary ChEBI ID | CHEBI:100146 |
| Last Modified | 23 November 2022 |
| Formula | C18H20FN3O4 |
| Net Charge | 0 |
| Average Mass | 361.373 |
| Monoisotopic Mass | 361.14378 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. antibacterial drug A drug used to treat or prevent bacterial infections. topoisomerase IV inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. DNA synthesis inhibitor Any substance that inhibits the synthesis of DNA. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. |
| Applications: | antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. anti-inflammatory agent Any compound that has anti-inflammatory effects. anti-ulcer drug One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. antibacterial drug A drug used to treat or prevent bacterial infections. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| ofloxacin (CHEBI:7731) has part dextrofloxacin (CHEBI:46577) |
| ofloxacin (CHEBI:7731) has part levofloxacin (CHEBI:63598) |
| ofloxacin (CHEBI:7731) has role anti-inflammatory agent (CHEBI:67079) |
| ofloxacin (CHEBI:7731) has role anti-ulcer drug (CHEBI:49201) |
| ofloxacin (CHEBI:7731) has role antibacterial agent (CHEBI:33282) |
| ofloxacin (CHEBI:7731) has role antibacterial drug (CHEBI:36047) |
| ofloxacin (CHEBI:7731) has role antiglaucoma drug (CHEBI:39456) |
| ofloxacin (CHEBI:7731) has role antihypertensive agent (CHEBI:35674) |
| ofloxacin (CHEBI:7731) has role antiinfective agent (CHEBI:35441) |
| ofloxacin (CHEBI:7731) has role DNA synthesis inhibitor (CHEBI:59517) |
| ofloxacin (CHEBI:7731) has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750) |
| ofloxacin (CHEBI:7731) has role ophthalmology drug (CHEBI:66981) |
| ofloxacin (CHEBI:7731) has role topoisomerase IV inhibitor (CHEBI:53559) |
| ofloxacin (CHEBI:7731) is a fluoroquinolone antibiotic (CHEBI:87211) |
| ofloxacin (CHEBI:7731) is a quinolone antibiotic (CHEBI:86324) |
| ofloxacin (CHEBI:7731) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid |
| INNs | Source |
|---|---|
| ofloxacin | WHO MedNet |
| ofloxacine | WHO MedNet |
| ofloxacino | WHO MedNet |
| ofloxacinum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (3RS)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid | IUPAC |
| rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid | ChEBI |
| rac-ofloxacin | ChEBI |
| HOE 280 | DrugBank |
| HOE-280 | DrugBank |
| J01MA01 | ChEMBL |
| Brand Names | Source |
|---|---|
| Exocin | ChEBI |
| Floxin | KEGG DRUG |
| Floxin otic | ChEMBL |
| Gailuoxian | DrugCentral |
| Ocuflox | ChemIDplus |
| Oxaldin | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:3657947 | Reaxys |
| CAS:82419-36-1 | ChemIDplus |
| CAS:82419-36-1 | KEGG COMPOUND |
| Citations |
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