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CHEBI:7731 - ofloxacin
| ChEBI ID | CHEBI:7731 |
| ChEBI Name | ofloxacin |
| Stars | |
| Definition | A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. |
| Secondary ChEBI ID | CHEBI:100146 |
| Last Modified | 23 November 2022 |
| Formula | C18H20FN3O4 |
| Net Charge | 0 |
| Average Mass | 361.373 |
| Monoisotopic Mass | 361.14378 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. antibacterial drug A drug used to treat or prevent bacterial infections. topoisomerase IV inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. DNA synthesis inhibitor Any substance that inhibits the synthesis of DNA. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. |
| Applications: | antibacterial drug A drug used to treat or prevent bacterial infections. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| ofloxacin (CHEBI:7731) has part dextrofloxacin (CHEBI:46577) |
| ofloxacin (CHEBI:7731) has part levofloxacin (CHEBI:63598) |
| ofloxacin (CHEBI:7731) has role antibacterial drug (CHEBI:36047) |
| ofloxacin (CHEBI:7731) has role antiinfective agent (CHEBI:35441) |
| ofloxacin (CHEBI:7731) has role DNA synthesis inhibitor (CHEBI:59517) |
| ofloxacin (CHEBI:7731) has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750) |
| ofloxacin (CHEBI:7731) has role topoisomerase IV inhibitor (CHEBI:53559) |
| ofloxacin (CHEBI:7731) is a fluoroquinolone antibiotic (CHEBI:87211) |
| ofloxacin (CHEBI:7731) is a quinolone antibiotic (CHEBI:86324) |
| ofloxacin (CHEBI:7731) is a racemate (CHEBI:60911) |
| IUPAC Name |
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| rac-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid |
| INNs | Source |
|---|---|
| ofloxacin | WHO MedNet |
| ofloxacine | WHO MedNet |
| ofloxacino | WHO MedNet |
| ofloxacinum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (3RS)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid | IUPAC |
| rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid | ChEBI |
| rac-ofloxacin | ChEBI |
| HOE 280 | DrugBank |
| HOE-280 | DrugBank |
| (±)-ofloxacin | ChEBI |
| Brand Names | Source |
|---|---|
| Exocin | ChEBI |
| Floxin | KEGG DRUG |
| Gailuoxian | DrugCentral |
| Ocuflox | ChemIDplus |
| Oxaldin | ChemIDplus |
| Prifloxcin | DrugCentral |
| Registry Numbers | Sources |
|---|---|
| Reaxys:3657947 | Reaxys |
| CAS:82419-36-1 | KEGG COMPOUND |
| CAS:82419-36-1 | ChemIDplus |
| Citations |
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