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CHEBI:7731 - ofloxacin
| ChEBI ID | CHEBI:7731 |
| ChEBI Name | ofloxacin |
| Stars | |
| Definition | A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. |
| Secondary ChEBI ID | CHEBI:100146 |
| Last Modified | 23 November 2022 |
| Formula | C18H20FN3O4 |
| Net Charge | 0 |
| Average Mass | 361.373 |
| Monoisotopic Mass | 361.14378 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | DNA synthesis inhibitor Any substance that inhibits the synthesis of DNA. antibacterial drug A drug used to treat or prevent bacterial infections. EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. topoisomerase IV inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. |
| Applications: | antibacterial drug A drug used to treat or prevent bacterial infections. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| ofloxacin (CHEBI:7731) has part dextrofloxacin (CHEBI:46577) |
| ofloxacin (CHEBI:7731) has part levofloxacin (CHEBI:63598) |
| ofloxacin (CHEBI:7731) has role antibacterial drug (CHEBI:36047) |
| ofloxacin (CHEBI:7731) has role antiinfective agent (CHEBI:35441) |
| ofloxacin (CHEBI:7731) has role DNA synthesis inhibitor (CHEBI:59517) |
| ofloxacin (CHEBI:7731) has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750) |
| ofloxacin (CHEBI:7731) has role topoisomerase IV inhibitor (CHEBI:53559) |
| ofloxacin (CHEBI:7731) is a fluoroquinolone antibiotic (CHEBI:87211) |
| ofloxacin (CHEBI:7731) is a quinolone antibiotic (CHEBI:86324) |
| ofloxacin (CHEBI:7731) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid |
| INNs | Source |
|---|---|
| ofloxacinum | WHO MedNet |
| ofloxacine | WHO MedNet |
| ofloxacin | WHO MedNet |
| ofloxacino | WHO MedNet |
| Synonyms | Source |
|---|---|
| DL 8280 | ChemIDplus |
| rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid | ChEBI |
| OFLX | KEGG DRUG |
| (±)-ofloxacin | ChEBI |
| racemic ofloxacin | ChEBI |
| rac-ofloxacin | ChEBI |
| Brand Names | Source |
|---|---|
| Prifloxin | DrugCentral |
| Prifloxcin | DrugCentral |
| Gailuoxian | DrugCentral |
| Oxaldin | ChemIDplus |
| Floxin | KEGG DRUG |
| Ocuflox | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:3657947 | Reaxys |
| CAS:82419-36-1 | KEGG COMPOUND |
| CAS:82419-36-1 | ChemIDplus |
| Citations |
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