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CHEBI:76703 - 5'-AsGsCsCsGsCsGsAsCsTsTsCsTsAsGsAsCsT-3'

ChEBI IDCHEBI:76703
ChEBI Name5'-AsGsCsCsGsCsGsAsCsTsTsCsTsAsGsAsCsT-3'
Stars
DefinitionA phosphorothioate oligonucleotide consisting of four deoxyguanosine, six deoxycytidine, four deoxyadenosine and four thymidine residues connected by 3'→5' phosphorothioate linkages in the sequence A-G-C-C-G-C-G-A-C-T-T-C-T-A-G-A-C-T.
Last Modified16 December 2013
SubmitterMarcus Ennis
DownloadsMolfile
FormulaC174H222N66O91P18S18
Net Charge0
Average Mass5828.799
Monoisotopic Mass5824.50226
SMILESCc1cn([C@H]2C[C@H](OP(=O)(O)S)[C@@H](COP(=O)(S)O[C@H]3C[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cnc5c(N)ncnc54)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cnc5c(=O)nc(N)nc54)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cnc5c(N)ncnc54)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cc(C)c(=O)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cc(C)c(=O)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cc(C)c(=O)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cnc5c(N)ncnc54)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cnc5c(=O)nc(N)nc54)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cnc5c(=O)nc(N)nc54)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cnc5c(=O)nc(N)nc54)O[C@@H]3COP(=O)(S)O[C@H]3C[C@H](n4cnc5c(N)ncnc54)O[C@@H]3CO)O2)c(=O)nc1=O
InChIInChI=1S/C174H222N66O91P18S18/c1-69-35-229(171(256)219-153(69)242)121-18-74(314-332(260,261)350)92(303-121)40-279-334(263,352)316-75-19-115(223-11-5-109(175)205-165(223)250)299-95(75)43-283-343(272,361)325-84-28-126(234-62-198-134-142(182)190-58-194-146(134)234)309-104(84)52-292-349(278,367)331-90-34-132(240-68-204-140-152(240)214-164(188)218-160(140)249)313-108(90)56-295-347(276,365)327-86-30-128(236-64-200-136-144(184)192-60-196-148(136)236)307-102(86)50-290-342(271,360)324-83-27-124(232-38-72(4)156(245)222-174(232)259)305-100(83)48-288-336(265,354)318-77-21-117(225-13-7-111(177)207-167(225)252)298-94(77)42-282-340(269,358)322-81-25-122(230-36-70(2)154(243)220-172(230)257)306-101(81)49-289-341(270,359)323-82-26-123(231-37-71(3)155(244)221-173(231)258)304-99(82)47-287-337(266,355)319-78-22-118(226-14-8-112(178)208-168(226)253)300-96(78)44-284-344(273,362)326-85-29-127(235-63-199-135-143(183)191-59-195-147(135)235)308-103(85)51-291-348(277,366)330-89-33-131(239-67-203-139-151(239)213-163(187)217-159(139)248)312-107(89)55-294-339(268,357)321-80-24-120(228-16-10-114(180)210-170(228)255)302-98(80)46-286-346(275,364)329-88-32-130(238-66-202-138-150(238)212-162(186)216-158(138)247)311-106(88)54-293-338(267,356)320-79-23-119(227-15-9-113(179)209-169(227)254)297-93(79)41-281-335(264,353)317-76-20-116(224-12-6-110(176)206-166(224)251)301-97(76)45-285-345(274,363)328-87-31-129(237-65-201-137-149(237)211-161(185)215-157(137)246)310-105(87)53-280-333(262,351)315-73-17-125(296-91(73)39-241)233-61-197-133-141(181)189-57-193-145(133)233/h5-16,35-38,57-68,73-108,115-132,241H,17-34,39-56H2,1-4H3,(H,262,351)(H,263,352)(H,264,353)(H,265,354)(H,266,355)(H,267,356)(H,268,357)(H,269,358)(H,270,359)(H,271,360)(H,272,361)(H,273,362)(H,274,363)(H,275,364)(H,276,365)(H,277,366)(H,278,367)(H2,175,205,250)(H2,176,206,251)(H2,177,207,252)(H2,178,208,253)(H2,179,209,254)(H2,180,210,255)(H2,181,189,193)(H2,182,190,194)(H2,183,191,195)(H2,184,192,196)(H,219,242,256)(H,220,243,257)(H,221,244,258)(H,222,245,259)(H2,260,261,350)(H3,185,211,215,246)(H3,186,212,216,247)(H3,187,213,217,248)(H3,188,214,218,249)/t73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,333?,334?,335?,336?,337?,338?,339?,340?,341?,342?,343?,344?,345?,346?,347?,348?,349?/m0/s1
InChIKeySVTKGMRDDNPLBL-ZDDQPSDESA-N
Roles Classification
Biological Roles:
antisense oligonucleotide  A synthetic oligonucleotide whose base sequence is complementary to a gene's messenger RNA (mRNA) and which will bind with the mRNA inactivating it.
antigen  Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
ChEBI Ontology
Outgoing Relation(s)
5'-AsGsCsCsGsCsGsAsCsTsTsCsTsAsGsAsCsT-3' (CHEBI:76703) has role antigen (CHEBI:59132)
5'-AsGsCsCsGsCsGsAsCsTsTsCsTsAsGsAsCsT-3' (CHEBI:76703) has role antisense oligonucleotide (CHEBI:76720)
5'-AsGsCsCsGsCsGsAsCsTsTsCsTsAsGsAsCsT-3' (CHEBI:76703) is a phosphorothioate oligonucleotide (CHEBI:76674)
Synonyms  Source
phosphorothioate-linked 5'-AGCCGCGACTTCTAGACT-3'ChEBI
[All-PS]-d(AGCCGCGACTTCTAGACT)ChEBI
d[APSGPSCPSCPSGPSCPSGPSAPSCPSTPSTPSCPSTPSAPSGPSAPSCPST]ChEBI
[PS]-5'-AGCCGCGACTTCTAGACT-3'ChEBI
phosphorothioate-linked 5'-AGC CGC GAC TTC TAG ACT-3'ChEBI
Citations