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CHEBI:76690 - 5'-TsGsTsGsGsGsTsTsAsAsGsAsCsTsTsTsTsTsAsCsC-3'

ChEBI IDCHEBI:76690
ChEBI Name5'-TsGsTsGsGsGsTsTsAsAsGsAsCsTsTsTsTsTsAsCsC-3'
Stars
DefinitionA phosphorothioate oligonucleotide consisting of five deoxyguanosine, three deoxycytidine, four deoxyadenosine and nine thymidine residues connected by 3'→5' phosphorothioate linkages in the sequence T-G-T-G-G-G-T-T-A-A-G-A-C-T-T-T-T-T-A-C-C.
Last Modified16 December 2013
SubmitterMarcus Ennis
DownloadsMolfile
FormulaC207H262N72O109P20S20
Net Charge0
Average Mass6763.588
Monoisotopic Mass6758.63383
SMILESCc1cn([C@H]2C[C@H](OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4ccc(N)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4ccc(N)nc4=O)C[C@@H]3OP(=O)(S)OC[C@H]3O[C@@H](n4ccc(N)nc4=O)C[C@@H]3O)[C@@H](CO)O2)c(=O)nc1=O
InChIInChI=1S/C207H262N72O109P20S20/c1-80-37-262(199(299)250-177(80)282)137-17-90(110(46-280)348-137)369-390(309,410)329-62-126-105(32-150(364-126)275-75-232-159-172(275)240-191(215)245-186(159)291)384-402(321,422)338-57-121-100(27-145(359-121)270-45-88(9)185(290)258-207(270)307)379-399(318,419)344-63-127-107(34-152(365-127)277-77-234-161-174(277)242-193(217)247-188(161)293)387-407(326,427)347-66-130-109(36-154(368-130)279-79-236-163-176(279)244-195(219)249-190(163)295)388-408(327,428)346-65-129-106(33-151(367-129)276-76-233-160-173(276)241-192(216)246-187(160)292)385-403(322,423)339-56-120-97(24-142(358-120)267-42-85(6)182(287)255-204(267)304)376-396(315,416)337-55-119-99(26-144(357-119)269-44-87(8)184(289)257-206(269)306)378-398(317,418)341-59-123-103(30-148(361-123)273-73-230-157-166(213)222-69-226-170(157)273)382-404(323,424)342-60-124-104(31-149(362-124)274-74-231-158-167(214)223-70-227-171(158)274)383-405(324,425)345-64-128-108(35-153(366-128)278-78-235-162-175(278)243-194(218)248-189(162)294)386-406(325,426)343-61-125-102(29-147(363-125)272-72-229-156-165(212)221-68-225-169(156)272)381-401(320,421)331-49-113-92(19-136(351-113)261-15-12-133(210)239-198(261)298)371-391(310,411)332-50-114-93(20-138(352-114)263-38-81(2)178(283)251-200(263)300)372-392(311,412)333-51-115-94(21-139(353-115)264-39-82(3)179(284)252-201(264)301)373-393(312,413)334-52-116-95(22-140(354-116)265-40-83(4)180(285)253-202(265)302)374-394(313,414)335-53-117-96(23-141(355-117)266-41-84(5)181(286)254-203(266)303)375-395(314,415)336-54-118-98(25-143(356-118)268-43-86(7)183(288)256-205(268)305)377-397(316,417)340-58-122-101(28-146(360-122)271-71-228-155-164(211)220-67-224-168(155)271)380-400(319,420)330-48-112-91(18-135(350-112)260-14-11-132(209)238-197(260)297)370-389(308,409)328-47-111-89(281)16-134(349-111)259-13-10-131(208)237-196(259)296/h10-15,37-45,67-79,89-130,134-154,280-281H,16-36,46-66H2,1-9H3,(H,308,409)(H,309,410)(H,310,411)(H,311,412)(H,312,413)(H,313,414)(H,314,415)(H,315,416)(H,316,417)(H,317,418)(H,318,419)(H,319,420)(H,320,421)(H,321,422)(H,322,423)(H,323,424)(H,324,425)(H,325,426)(H,326,427)(H,327,428)(H2,208,237,296)(H2,209,238,297)(H2,210,239,298)(H2,211,220,224)(H2,212,221,225)(H2,213,222,226)(H2,214,223,227)(H,250,282,299)(H,251,283,300)(H,252,284,301)(H,253,285,302)(H,254,286,303)(H,255,287,304)(H,256,288,305)(H,257,289,306)(H,258,290,307)(H3,215,240,245,291)(H3,216,241,246,292)(H3,217,242,247,293)(H3,218,243,248,294)(H3,219,244,249,295)/t89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110+,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,134+,135+,136+,137+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,148+,149+,150+,151+,152+,153+,154+,389?,390?,391?,392?,393?,394?,395?,396?,397?,398?,399?,400?,401?,402?,403?,404?,405?,406?,407?,408?/m0/s1
InChIKeyRLFIMNRWDHQJTR-DOFQEIFCSA-N
Roles Classification
Biological Roles:
antisense oligonucleotide  A synthetic oligonucleotide whose base sequence is complementary to a gene's messenger RNA (mRNA) and which will bind with the mRNA inactivating it.
antigen  Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
ChEBI Ontology
Outgoing Relation(s)
5'-TsGsTsGsGsGsTsTsAsAsGsAsCsTsTsTsTsTsAsCsC-3' (CHEBI:76690) has role antigen (CHEBI:59132)
5'-TsGsTsGsGsGsTsTsAsAsGsAsCsTsTsTsTsTsAsCsC-3' (CHEBI:76690) has role antisense oligonucleotide (CHEBI:76720)
5'-TsGsTsGsGsGsTsTsAsAsGsAsCsTsTsTsTsTsAsCsC-3' (CHEBI:76690) is a phosphorothioate oligonucleotide (CHEBI:76674)
Synonyms  Source
phosphorothioate-linked 5'-TGTGGGTTAAGACTTTTTACC-3'ChEBI
[PS]-5'-TGTGGGTTAAGACTTTTTACC-3'ChEBI
[All-PS]-d(TGTGGGTTAAGACTTTTTACC)ChEBI
d[TPSGPSTPSGPSGPSGPSTPSTPSAPSAPSGPSAPSCPSTPSTPSTPSTPSTPSPSAPSCPSC]ChEBI
phosphorothioate-linked 5'-TGT GGG TTA AGA CTT TTT ACC-3'ChEBI
Citations