EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:76207 - mavacoxib

ChEBI IDCHEBI:76207
ChEBI Namemavacoxib
Stars
DefinitionA member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and 4-fluorophenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine to treat pain and inflammation in dogs with degenerative joint disease.
Last Modified3 December 2013
SubmitterSteve
DownloadsMolfile
FormulaC16H11F4N3O2S
Net Charge0
Average Mass385.342
Monoisotopic Mass385.05081
SMILESNS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(F)cc2)cc1
InChIInChI=1S/C16H11F4N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)
InChIKeyTTZNQDOUNXBMJV-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
cyclooxygenase 2 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Applications:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
ChEBI Ontology
Outgoing Relation(s)
mavacoxib (CHEBI:76207) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
mavacoxib (CHEBI:76207) has role non-narcotic analgesic (CHEBI:35481)
mavacoxib (CHEBI:76207) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
mavacoxib (CHEBI:76207) is a organofluorine compound (CHEBI:37143)
mavacoxib (CHEBI:76207) is a pyrazoles (CHEBI:26410)
mavacoxib (CHEBI:76207) is a sulfonamide (CHEBI:35358)
IUPAC Name 
4-[5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
INNs  Source
mavacoxibKEGG DRUG
mavacoxibumWHO MedNet
mavacoxibWHO MedNet
mavacoxibWHO MedNet
Synonyms  Source
PHA-739521ChemIDplus
PHA 739,521ChemIDplus
Manual XrefsDatabases
D04863KEGG DRUG
US2005222240Patent
WO2005025510Patent
WO2006024930Patent
MavacoxibWikipedia
1875VSDB
Registry NumbersSources
Reaxys:7726438Reaxys
CAS:170569-88-7KEGG DRUG
CAS:170569-88-7ChemIDplus
Citations