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CHEBI:76201 - clonixin lysine salt

Default Structure
ChEBI IDCHEBI:76201
ChEBI Nameclonixin lysine salt
Stars
DefinitionAn organoammonium salt obtained by combining clonixin with one molar equivalent of L-lysine. Used for treatment of renal colic, muscular pain and moderately severe migraine attacks.
Last Modified25 February 2016
SubmitterSteve
DownloadsMolfile
FormulaC13H11ClN2O2.C6H14N2O2
Net Charge0
Average Mass408.886
Monoisotopic Mass408.15643
SMILESCc1c(Cl)cccc1Nc1ncccc1C(=O)O.NCCCC[C@H](N)C(=O)O
InChIInChI=1S/C13H11ClN2O2.C6H14N2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12;7-4-2-1-3-5(8)6(9)10/h2-7H,1H3,(H,15,16)(H,17,18);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1
InChIKeyCVNFYQCHAWFYQI-ZSCHJXSPSA-N
Wikipedia
Roles Classification
Biological Roles:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
lipoxygenase inhibitor  A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor  A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Applications:
vasodilator agent  A drug used to cause dilation of the blood vessels.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
antipyretic  A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
ChEBI Ontology
Outgoing Relation(s)
clonixin lysine salt (CHEBI:76201) has part L-lysinium(1+) (CHEBI:32551)
clonixin lysine salt (CHEBI:76201) has part clonixin(1−) (CHEBI:76203)
clonixin lysine salt (CHEBI:76201) has role antipyretic (CHEBI:35493)
clonixin lysine salt (CHEBI:76201) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
clonixin lysine salt (CHEBI:76201) has role lipoxygenase inhibitor (CHEBI:35856)
clonixin lysine salt (CHEBI:76201) has role non-narcotic analgesic (CHEBI:35481)
clonixin lysine salt (CHEBI:76201) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
clonixin lysine salt (CHEBI:76201) has role platelet aggregation inhibitor (CHEBI:50427)
clonixin lysine salt (CHEBI:76201) has role vasodilator agent (CHEBI:35620)
clonixin lysine salt (CHEBI:76201) is a organoammonium salt (CHEBI:46850)
IUPAC Names 
2-[(3-chloro-2-methylphenyl)amino]nicotinic acid—L-lysine (1/1)
(2S)-2,6-diazaniumylhexanoate 2-[(3-chloro-2-methylphenyl)amino]nicotinate
Synonyms  Source
2-(2'-Methyl-3'-chloroanilino)lysine nicotinateChemIDplus
L 104ChemIDplus
L-Lysine, mono(2-((3-chloro-2-methylphenyl)amino)-3-pyridinecarboxylate)ChemIDplus
Lysine clonixinateChemIDplus
L-clonixin lysine saltChEBI
L-lysine clonixinateChEBI
Manual XrefsDatabases
ClonixinWikipedia
D07728KEGG DRUG
LSM-6703LINCS
MX2007012517Patent
US5444076Patent
US5626872Patent
Registry NumbersSources
Reaxys:7242905Reaxys
CAS:55837-30-4ChemIDplus
CAS:55837-30-4KEGG DRUG
Citations