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CHEBI:76201 - clonixin lysine salt

Default Structure
ChEBI IDCHEBI:76201
ChEBI Nameclonixin lysine salt
Stars
DefinitionAn organoammonium salt obtained by combining clonixin with one molar equivalent of L-lysine. Used for treatment of renal colic, muscular pain and moderately severe migraine attacks.
Last Modified25 February 2016
SubmitterSteve
DownloadsMolfile
FormulaC13H11ClN2O2.C6H14N2O2
Net Charge0
Average Mass408.886
Monoisotopic Mass408.15643
SMILESCc1c(Cl)cccc1Nc1ncccc1C(=O)O.NCCCC[C@H](N)C(=O)O
InChIInChI=1S/C13H11ClN2O2.C6H14N2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12;7-4-2-1-3-5(8)6(9)10/h2-7H,1H3,(H,15,16)(H,17,18);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1
InChIKeyCVNFYQCHAWFYQI-ZSCHJXSPSA-N
Wikipedia
Roles Classification
Biological Roles:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor  A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
lipoxygenase inhibitor  A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.
Applications:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
vasodilator agent  A drug used to cause dilation of the blood vessels.
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
antipyretic  A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
ChEBI Ontology
Outgoing Relation(s)
clonixin lysine salt (CHEBI:76201) has part L-lysinium(1+) (CHEBI:32551)
clonixin lysine salt (CHEBI:76201) has part clonixin(1−) (CHEBI:76203)
clonixin lysine salt (CHEBI:76201) has role antipyretic (CHEBI:35493)
clonixin lysine salt (CHEBI:76201) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
clonixin lysine salt (CHEBI:76201) has role lipoxygenase inhibitor (CHEBI:35856)
clonixin lysine salt (CHEBI:76201) has role non-narcotic analgesic (CHEBI:35481)
clonixin lysine salt (CHEBI:76201) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
clonixin lysine salt (CHEBI:76201) has role platelet aggregation inhibitor (CHEBI:50427)
clonixin lysine salt (CHEBI:76201) has role vasodilator agent (CHEBI:35620)
clonixin lysine salt (CHEBI:76201) is a organoammonium salt (CHEBI:46850)
IUPAC Names 
2-[(3-chloro-2-methylphenyl)amino]nicotinic acid—L-lysine (1/1)
(2S)-2,6-diazaniumylhexanoate 2-[(3-chloro-2-methylphenyl)amino]nicotinate
Synonyms  Source
2-(2'-Methyl-3'-chloroanilino)lysine nicotinateChemIDplus
L 104ChemIDplus
L-Lysine, mono(2-((3-chloro-2-methylphenyl)amino)-3-pyridinecarboxylate)ChemIDplus
Lysine clonixinateChemIDplus
L-clonixin lysine saltChEBI
L-lysine clonixinateChEBI
Manual XrefsDatabases
ClonixinWikipedia
D07728KEGG DRUG
LSM-6703LINCS
MX2007012517Patent
US5444076Patent
US5626872Patent
Registry NumbersSources
Reaxys:7242905Reaxys
CAS:55837-30-4ChemIDplus
CAS:55837-30-4KEGG DRUG
Citations