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CHEBI:76198 - loxoprofen sodium

ChEBI IDCHEBI:76198
ChEBI Nameloxoprofen sodium
Stars
DefinitionAn organic sodium salt having loxoprofen(1−) as the counterion. The parent acid, loxoprofen, is a prodrug that is rapidly converted to its active trans-alcohol metabolite following oral administration.
Last Modified5 November 2013
SubmitterSteve
DownloadsMolfile
FormulaC15H17O3.Na
Net Charge0
Average Mass268.288
Monoisotopic Mass268.10754
SMILESCC(C(=O)[O-])c1ccc(CC2CCCC2=O)cc1.[Na+]
InChIInChI=1S/C15H18O3.Na/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);/q;+1/p-1
InChIKeyWORCCYVLMMTGFR-UHFFFAOYSA-M
Wikipedia
Roles Classification
Biological Roles:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor  A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Applications:
antipyretic  A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
ChEBI Ontology
Outgoing Relation(s)
loxoprofen sodium (CHEBI:76198) has part loxoprofen(1−) (CHEBI:76199)
loxoprofen sodium (CHEBI:76198) has role antipyretic (CHEBI:35493)
loxoprofen sodium (CHEBI:76198) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
loxoprofen sodium (CHEBI:76198) has role non-narcotic analgesic (CHEBI:35481)
loxoprofen sodium (CHEBI:76198) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
loxoprofen sodium (CHEBI:76198) is a organic sodium salt (CHEBI:38700)
Incoming Relation(s)
loxoprofen sodium hydrate (CHEBI:31786) has part loxoprofen sodium (CHEBI:76198)
IUPAC Name 
sodium 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoate
Synonym  Source
loxoprofen sodium saltChEBI
Manual XrefsDatabases
LoxoprofenWikipedia
Registry NumbersSources
Reaxys:5686164Reaxys