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CHEBI:76138 - flunixin

ChEBI IDCHEBI:76138
ChEBI Nameflunixin
Stars
DefinitionA pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs.
Last Modified15 June 2017
SubmitterSteve
DownloadsMolfile
FormulaC14H11F3N2O2
Net Charge0
Average Mass296.248
Monoisotopic Mass296.07726
SMILESCc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F
InChIInChI=1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)
InChIKeyNOOCSNJCXJYGPE-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Roles:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Roles:
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor  A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Applications:
antipyretic  A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
ChEBI Ontology
Outgoing Relation(s)
flunixin (CHEBI:76138) has functional parent nicotinic acid (CHEBI:15940)
flunixin (CHEBI:76138) has role antipyretic (CHEBI:35493)
flunixin (CHEBI:76138) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
flunixin (CHEBI:76138) has role non-narcotic analgesic (CHEBI:35481)
flunixin (CHEBI:76138) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
flunixin (CHEBI:76138) is a aminopyridine (CHEBI:38207)
flunixin (CHEBI:76138) is a organofluorine compound (CHEBI:37143)
flunixin (CHEBI:76138) is a pyridinemonocarboxylic acid (CHEBI:26420)
flunixin (CHEBI:76138) is conjugate acid of flunixin(1−) (CHEBI:76153)
Incoming Relation(s)
flunixin(1−) (CHEBI:76153) is conjugate base of flunixin (CHEBI:76138)
IUPAC Name 
2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid
INNs  Source
flunixinKEGG DRUG
flunixineChemIDplus
flunixinumChemIDplus
flunixinoChemIDplus
Synonyms  Source
2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acidChemIDplus
Sch 14714ChemIDplus
2-(α3,α3,α3-trifluoro-2,3-xylidino)nicotinic acidChemIDplus
Manual XrefsDatabases
D04215KEGG DRUG
US2008014272Patent
US5637617Patent
FlunixinWikipedia
1802VSDB
Registry NumbersSources
Reaxys:492802Reaxys
CAS:38677-85-9KEGG DRUG
CAS:38677-85-9ChemIDplus
Citations