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CHEBI:75922 - nepafenac

Default Structure
ChEBI IDCHEBI:75922
ChEBI Namenepafenac
Stars
DefinitionA monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery.
Last Modified28 April 2020
SubmitterGareth Owen
DownloadsMolfile
FormulaC15H14N2O2
Net Charge0
Average Mass254.289
Monoisotopic Mass254.10553
SMILESNC(=O)Cc1cccc(C(=O)c2ccccc2)c1N
InChIInChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChIKeyQEFAQIPZVLVERP-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
cyclooxygenase 2 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
cyclooxygenase 1 inhibitor  A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
Applications:
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
ophthalmology drug  Any compound used for the treatment of eye conditions or eye diseases.
ChEBI Ontology
Outgoing Relation(s)
nepafenac (CHEBI:75922) has role analgesic (CHEBI:35480)
nepafenac (CHEBI:75922) has role anti-inflammatory agent (CHEBI:67079)
nepafenac (CHEBI:75922) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
nepafenac (CHEBI:75922) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
nepafenac (CHEBI:75922) has role non-narcotic analgesic (CHEBI:35481)
nepafenac (CHEBI:75922) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
nepafenac (CHEBI:75922) has role ophthalmology drug (CHEBI:66981)
nepafenac (CHEBI:75922) has role prodrug (CHEBI:50266)
nepafenac (CHEBI:75922) is a monocarboxylic acid amide (CHEBI:29347)
IUPAC Name 
2-(2-amino-3-benzoylphenyl)acetamide
INNs  Source
nepafenacChemIDplus
népafénacWHO MedNet
nepafenacoWHO MedNet
nepafenacumWHO MedNet
Synonyms  Source
2-amino-3-benzoylbenzeneacetamideChemIDplus
AHR 9434ChemIDplus
AHR-9434ChemIDplus
AL 6515ChemIDplus
AL-6515ChemIDplus
Brand Names  Source
IlevroChEMBL
NevanacKEGG DRUG
Manual XrefsDatabases
1899DrugCentral
D05143KEGG DRUG
DB06802DrugBank
HMDB0015678HMDB
NepafenacWikipedia
Registry NumbersSources
Reaxys:4256257Reaxys
CAS:78281-72-8ChemIDplus
Citations