EMBL-EBI | Chemical Biology Resources | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:7550 - nicardipine
| ChEBI ID | CHEBI:7550 |
| ChEBI Name | nicardipine |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension. |
| Last Modified | 14 October 2021 |
| Formula | C26H29N3O6 |
| Net Charge | 0 |
| Average Mass | 479.533 |
| Monoisotopic Mass | 479.20564 |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | autophagy inhibitor Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell). calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. vasodilator agent A drug used to cause dilation of the blood vessels. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nicardipine (CHEBI:7550) has part (R)-nicardipine (CHEBI:180904) |
| nicardipine (CHEBI:7550) has part (S)-nicardipine (CHEBI:135777) |
| nicardipine (CHEBI:7550) has role antihypertensive agent (CHEBI:35674) |
| nicardipine (CHEBI:7550) has role antineoplastic agent (CHEBI:35610) |
| nicardipine (CHEBI:7550) has role autophagy inhibitor (CHEBI:88230) |
| nicardipine (CHEBI:7550) has role calcium channel blocker (CHEBI:38215) |
| nicardipine (CHEBI:7550) has role cardiovascular drug (CHEBI:35554) |
| nicardipine (CHEBI:7550) has role vasodilator agent (CHEBI:35620) |
| nicardipine (CHEBI:7550) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| 2-[benzyl(methyl)amino]ethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| INNs | Source |
|---|---|
| nicardipine | WHO MedNet |
| nicardipine | WHO MedNet |
| nicardipineum | WHO MedNet |
| nicardipino | WHO MedNet |
| Synonyms | Source |
|---|---|
| rac-nicardipine | ChEBI |
| (RS)-nicardipine | ChEBI |
| (±)-nicardipine | DrugCentral |
| Nicardipine (stn) | ChEMBL |
| perpidine | DrugCentral |
| racemic nicardipine | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| 1909 | DrugCentral |
| 4319 | ChemSpider |
| C07264 | KEGG COMPOUND |
| D08270 | KEGG DRUG |
| DB00622 | DrugBank |
| HMDB0014760 | HMDB |
| LSM-1418 | LINCS |
| Nicardipine | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:504321 | Reaxys |
| CAS:55985-32-5 | ChemIDplus |
| Citations |
|---|