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CHEBI:7550 - nicardipine
| ChEBI ID | CHEBI:7550 |
| ChEBI Name | nicardipine |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension. |
| Last Modified | 14 October 2021 |
| Formula | C26H29N3O6 |
| Net Charge | 0 |
| Average Mass | 479.533 |
| Monoisotopic Mass | 479.20564 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | autophagy inhibitor Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell). calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. |
| Applications: | vasodilator agent A drug used to cause dilation of the blood vessels. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nicardipine (CHEBI:7550) has part (R)-nicardipine (CHEBI:180904) |
| nicardipine (CHEBI:7550) has part (S)-nicardipine (CHEBI:135777) |
| nicardipine (CHEBI:7550) has role antihypertensive agent (CHEBI:35674) |
| nicardipine (CHEBI:7550) has role autophagy inhibitor (CHEBI:88230) |
| nicardipine (CHEBI:7550) has role calcium channel blocker (CHEBI:38215) |
| nicardipine (CHEBI:7550) has role vasodilator agent (CHEBI:35620) |
| nicardipine (CHEBI:7550) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| 2-[benzyl(methyl)amino]ethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| INNs | Source |
|---|---|
| nicardipine | WHO MedNet |
| nicardipine | WHO MedNet |
| nicardipineum | WHO MedNet |
| nicardipino | WHO MedNet |
| Synonyms | Source |
|---|---|
| rac-nicardipine | ChEBI |
| (RS)-nicardipine | ChEBI |
| (±)-nicardipine | DrugCentral |
| perpidine | DrugCentral |
| racemic nicardipine | ChEBI |
| YC-93 free base | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| 1909 | DrugCentral |
| 4319 | ChemSpider |
| C07264 | KEGG COMPOUND |
| D08270 | KEGG DRUG |
| DB00622 | DrugBank |
| HMDB0014760 | HMDB |
| LSM-1418 | LINCS |
| Nicardipine | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:504321 | Reaxys |
| CAS:55985-32-5 | ChemIDplus |
| Citations |
|---|