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CHEBI:7550 - nicardipine
| ChEBI ID | CHEBI:7550 |
| ChEBI Name | nicardipine |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension. |
| Last Modified | 14 October 2021 |
| Formula | C26H29N3O6 |
| Net Charge | 0 |
| Average Mass | 479.533 |
| Monoisotopic Mass | 479.20564 |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. autophagy inhibitor Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell). |
| Applications: | antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. vasodilator agent A drug used to cause dilation of the blood vessels. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nicardipine (CHEBI:7550) has part (R)-nicardipine (CHEBI:180904) |
| nicardipine (CHEBI:7550) has part (S)-nicardipine (CHEBI:135777) |
| nicardipine (CHEBI:7550) has role antihypertensive agent (CHEBI:35674) |
| nicardipine (CHEBI:7550) has role autophagy inhibitor (CHEBI:88230) |
| nicardipine (CHEBI:7550) has role calcium channel blocker (CHEBI:38215) |
| nicardipine (CHEBI:7550) has role vasodilator agent (CHEBI:35620) |
| nicardipine (CHEBI:7550) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| 2-[benzyl(methyl)amino]ethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| INNs | Source |
|---|---|
| nicardipine | WHO MedNet |
| nicardipino | WHO MedNet |
| nicardipine | WHO MedNet |
| nicardipineum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (±)-nicardipine | DrugCentral |
| perpidine | DrugCentral |
| (RS)-nicardipine | ChEBI |
| rac-nicardipine | ChEBI |
| racemic nicardipine | ChEBI |
| YC-93 free base | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| C07264 | KEGG COMPOUND |
| D08270 | KEGG DRUG |
| LSM-1418 | LINCS |
| 1909 | DrugCentral |
| HMDB0014760 | HMDB |
| DB00622 | DrugBank |
| Nicardipine | Wikipedia |
| 4319 | ChemSpider |
| Registry Numbers | Sources |
|---|---|
| Reaxys:504321 | Reaxys |
| CAS:55985-32-5 | ChemIDplus |
| Citations |
|---|