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CHEBI:75179 - trifluridine

ChEBI IDCHEBI:75179
ChEBI Nametrifluridine
Stars
DefinitionA pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.
Secondary ChEBI IDCHEBI:9713
Last Modified22 February 2017
SubmitterSteve
DownloadsMolfile
FormulaC10H11F3N2O5
Net Charge0
Average Mass296.201
Monoisotopic Mass296.06201
SMILESO=c1nc(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1C(F)(F)F
InChIInChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChIKeyVSQQQLOSPVPRAZ-RRKCRQDMSA-N
Wikipedia
Roles Classification
Biological Roles:
antimetabolite  A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
EC 2.1.1.45 (thymidylate synthase) inhibitor  An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of thymidylate synthase (EC 2.1.1.45).
antiviral drug  A substance used in the prophylaxis or therapy of virus diseases.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antiviral drug  A substance used in the prophylaxis or therapy of virus diseases.
ChEBI Ontology
Outgoing Relation(s)
trifluridine (CHEBI:75179) has role antimetabolite (CHEBI:35221)
trifluridine (CHEBI:75179) has role antineoplastic agent (CHEBI:35610)
trifluridine (CHEBI:75179) has role antiviral drug (CHEBI:36044)
trifluridine (CHEBI:75179) has role EC 2.1.1.45 (thymidylate synthase) inhibitor (CHEBI:63720)
trifluridine (CHEBI:75179) is a nucleoside analogue (CHEBI:60783)
trifluridine (CHEBI:75179) is a organofluorine compound (CHEBI:37143)
trifluridine (CHEBI:75179) is a pyrimidine 2'-deoxyribonucleoside (CHEBI:19255)
Incoming Relation(s)
Lonsurf (CHEBI:90876) has part trifluridine (CHEBI:75179)
IUPAC Name 
2'-deoxy-5-(trifluoromethyl)uridine
INNs  Source
trifluridinaDrugBank
trifluridineDrugBank
trifluridinumChemIDplus
trifluridineWHO MedNet
Synonyms  Source
trifluorothymine deoxyribosideDrugBank
TrifluorothymidineDrugBank
TrifluoromethyldeoxyuridineDrugBank
5-Trifluoromethyl-2-deoxyuridineChemIDplus
5-(Trifluoromethyl)deoxyuridineChemIDplus
Brand Name  Source
ViropticKEGG DRUG
Manual XrefsDatabases
DB00432DrugBank
D00391KEGG DRUG
HMDB0014576HMDB
TrifluridineWikipedia
LSM-5217LINCS
2743DrugCentral
Registry NumbersSources
Reaxys:568095Reaxys
CAS:70-00-8KEGG DRUG
CAS:70-00-8ChemIDplus
Citations