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CHEBI:7494 - nefazodone
| Formula | C25H32ClN5O2 |
| Net Charge | 0 |
| Average Mass | 470.017 |
| Monoisotopic Mass | 469.22445 |
| SMILES | CCc1nn(CCCN2CCN(c3cccc(Cl)c3)CC2)c(=O)n1CCOc1ccccc1 |
| InChI | InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3 |
| InChIKey | VRBKIVRKKCLPHA-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nefazodone (CHEBI:7494) has role analgesic (CHEBI:35480) |
| nefazodone (CHEBI:7494) has role antidepressant (CHEBI:35469) |
| nefazodone (CHEBI:7494) has role serotonergic antagonist (CHEBI:48279) |
| nefazodone (CHEBI:7494) has role serotonin uptake inhibitor (CHEBI:50949) |
| nefazodone (CHEBI:7494) has role α-adrenergic antagonist (CHEBI:37890) |
| nefazodone (CHEBI:7494) is a N-alkylpiperazine (CHEBI:46845) |
| nefazodone (CHEBI:7494) is a N-arylpiperazine (CHEBI:46848) |
| nefazodone (CHEBI:7494) is a aromatic ether (CHEBI:35618) |
| nefazodone (CHEBI:7494) is a monochlorobenzenes (CHEBI:83403) |
| nefazodone (CHEBI:7494) is a triazoles (CHEBI:35727) |
| Incoming Relation(s) |
| nefazodone hydrochloride (CHEBI:7495) has part nefazodone (CHEBI:7494) |
| IUPAC Name |
|---|
| 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one |
| INNs | Source |
|---|---|
| nefazodona | WHO MedNet |
| nefazodone | WHO MedNet |
| nefazodonum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one | ChemIDplus |
| Nefazodone | KEGG COMPOUND |
| néfazodone | ChEBI |
| Registry Numbers | Sources |
|---|---|
| Beilstein:4728403 | Beilstein |
| CAS:83366-66-9 | ChemIDplus |