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CHEBI:7494 - nefazodone
| Formula | C25H32ClN5O2 |
| Net Charge | 0 |
| Average Mass | 470.017 |
| Monoisotopic Mass | 469.22445 |
| SMILES | CCc1nn(CCCN2CCN(c3cccc(Cl)c3)CC2)c(=O)n1CCOc1ccccc1 |
| InChI | InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3 |
| InChIKey | VRBKIVRKKCLPHA-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nefazodone (CHEBI:7494) has role analgesic (CHEBI:35480) |
| nefazodone (CHEBI:7494) has role antidepressant (CHEBI:35469) |
| nefazodone (CHEBI:7494) has role serotonergic antagonist (CHEBI:48279) |
| nefazodone (CHEBI:7494) has role serotonin uptake inhibitor (CHEBI:50949) |
| nefazodone (CHEBI:7494) has role α-adrenergic antagonist (CHEBI:37890) |
| nefazodone (CHEBI:7494) is a N-alkylpiperazine (CHEBI:46845) |
| nefazodone (CHEBI:7494) is a N-arylpiperazine (CHEBI:46848) |
| nefazodone (CHEBI:7494) is a aromatic ether (CHEBI:35618) |
| nefazodone (CHEBI:7494) is a monochlorobenzenes (CHEBI:83403) |
| nefazodone (CHEBI:7494) is a triazoles (CHEBI:35727) |
| Incoming Relation(s) |
| nefazodone hydrochloride (CHEBI:7495) has part nefazodone (CHEBI:7494) |
| IUPAC Name |
|---|
| 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one |
| INNs | Source |
|---|---|
| nefazodone | WHO MedNet |
| nefazodonum | WHO MedNet |
| nefazodona | WHO MedNet |
| Synonyms | Source |
|---|---|
| Nefazodone | KEGG COMPOUND |
| néfazodone | ChEBI |
| 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Beilstein:4728403 | Beilstein |
| CAS:83366-66-9 | ChemIDplus |