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CHEBI:746867 - Remibrutinib

Default Structure
ChEBI IDCHEBI:746867
ChEBI NameRemibrutinib
Stars
DefinitionA small molecule Bruton's tyrosine kinase (BTK) inhibitor, indicated for the treatment of chronic spontaneous urticaria in adults.
Last Modified16 October 2025
SubmitterAnneNiknejad
DownloadsMolfile
FormulaC27H27F2N5O3
Net Charge0
Average Mass507.541
Monoisotopic Mass507.20820
SMILESC=CC(=O)N(C)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C
InChIInChI=1S/C27H27F2N5O3/c1-4-23(35)34(3)9-10-37-25-24(31-14-32-26(25)30)20-12-18(28)13-22(15(20)2)33-27(36)19-8-7-17(11-21(19)29)16-5-6-16/h4,7-8,11-14,16H,1,5-6,9-10H2,2-3H3,(H,33,36)(H2,30,31,32)
InChIKeyCUABMPOJOBCXJI-UHFFFAOYSA-N
Roles Classification
Biological Roles:
immunosuppressive agent  An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
tyrosine kinase inhibitor  Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
Application:
immunosuppressive agent  An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
ChEBI Ontology
Outgoing Relation(s)
Remibrutinib (CHEBI:746867) has role immunosuppressive agent (CHEBI:35705)
Remibrutinib (CHEBI:746867) has role tyrosine kinase inhibitor (CHEBI:38637)
Remibrutinib (CHEBI:746867) is a benzamides (CHEBI:22702)
Remibrutinib (CHEBI:746867) is a monofluorobenzenes (CHEBI:83575)
Remibrutinib (CHEBI:746867) is a organic molecular entity (CHEBI:50860)
Remibrutinib (CHEBI:746867) is a secondary carboxamide (CHEBI:140325)
Synonyms  Source
LOU064-NXAChEMBL
NVP-LOU064-NXAChEMBL
RemibrutinibChEMBL
Brand Name  Source
RhapsidoKEGG DRUG
Manual XrefsDatabases
D12285KEGG DRUG
Registry NumbersSources
CAS:1787294-07-8KEGG DRUG
Citations