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CHEBI:71417 - procarbazine

ChEBI IDCHEBI:71417
ChEBI Nameprocarbazine
Stars
DefinitionA benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Secondary ChEBI IDCHEBI:8432
Last Modified22 February 2017
DownloadsMolfile
FormulaC12H19N3O
Net Charge0
Average Mass221.304
Monoisotopic Mass221.15281
SMILESCNNCc1ccc(C(=O)NC(C)C)cc1
InChIInChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)
InChIKeyCPTBDICYNRMXFX-UHFFFAOYSA-N
Wikipedia
Roles Classification
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
procarbazine (CHEBI:71417) has role antineoplastic agent (CHEBI:35610)
procarbazine (CHEBI:71417) is a benzamides (CHEBI:22702)
procarbazine (CHEBI:71417) is a hydrazines (CHEBI:24631)
procarbazine (CHEBI:71417) is conjugate base of procarbazine(1+) (CHEBI:71431)
Incoming Relation(s)
procarbazine(1+) (CHEBI:71431) is conjugate acid of procarbazine (CHEBI:71417)
IUPAC Name 
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
INNs  Source
procarbazineKEGG DRUG
procarbazinaDrugBank
procarbazinumDrugBank
procarbazineWHO MedNet
Synonyms  Source
ProcarbazinDrugBank
2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazineChemIDplus
4-((2-Methylhydrazino)methyl)-N-isopropylbenzamideChemIDplus
N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamideChemIDplus
N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamideChemIDplus
N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazineChemIDplus
Manual XrefsDatabases
C07402KEGG COMPOUND
D08423KEGG DRUG
DB01168DrugBank
US3830840Patent
US2008107661Patent
US2007122414Patent
US3520926Patent
BE618638Patent
HMDB0015299HMDB
ProcarbazineWikipedia
LSM-2272LINCS
2272DrugCentral
Registry NumbersSources
Reaxys:958270Reaxys
CAS:671-16-9KEGG COMPOUND
CAS:671-16-9ChemIDplus
CAS:671-16-9NIST Chemistry WebBook
Citations